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Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial.

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Title: Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial.
Authors: Walther N; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; Charité Research Organisation GmbH, Berlin, Germany., Schultz-Heienbrok R; Charité Research Organisation GmbH, Berlin, Germany., Staß H; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany., Corman VM; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research, Braunschweig, Germany., Gassen NC; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Müller MA; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research, Braunschweig, Germany., Drosten C; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research, Braunschweig, Germany., Witzenrath M; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Lung Research, Berlin, Germany., Lee H; Charité Research Organisation GmbH, Berlin, Germany., Posch MG; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Source: PloS one [PLoS One] 2025 Feb 25; Vol. 20 (2), pp. e0303924. Date of Electronic Publication: 2025 Feb 25 (Print Publication: 2025).
Publication Type: Journal Article; Randomized Controlled Trial; Comparative Study
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Walther+N%22">Walther N</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; Charité Research Organisation GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schultz-Heienbrok+R%22">Schultz-Heienbrok R</searchLink>; Charité Research Organisation GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Staß+H%22">Staß H</searchLink>; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Corman+VM%22">Corman VM</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Gassen+NC%22">Gassen NC</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+MA%22">Müller MA</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Drosten+C%22">Drosten C</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Witzenrath+M%22">Witzenrath M</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Lung Research, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Charité Research Organisation GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Posch+MG%22">Posch MG</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2025 Feb 25; Vol. 20 (2), pp. e0303924. <i>Date of Electronic Publication: </i>2025 Feb 25 (<i>Print Publication: </i>2025).
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