Anticholinergic Burden and Cognitive Function in Psychosis: A Systematic Review and Meta-Analysis.

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Title: Anticholinergic Burden and Cognitive Function in Psychosis: A Systematic Review and Meta-Analysis.
Authors: Mancini V; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., Latreche C; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., Fanshawe JB; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., Varvari I; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., Zauchenberger CZ; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., McGinn N; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., Catalan A; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., Pillinger T; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., McGuire PK; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger)., McCutcheon RA; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).
Source: The American journal of psychiatry [Am J Psychiatry] 2025 Apr 01; Vol. 182 (4), pp. 349-359. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: American Psychiatric Association Country of Publication: United States NLM ID: 0370512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7228 (Electronic) Linking ISSN: 0002953X NLM ISO Abbreviation: Am J Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Anticholinergic Burden and Cognitive Function in Psychosis: A Systematic Review and Meta-Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Mancini+V%22">Mancini V</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22Latreche+C%22">Latreche C</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22Fanshawe+JB%22">Fanshawe JB</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22Varvari+I%22">Varvari I</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22Zauchenberger+CZ%22">Zauchenberger CZ</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22McGinn+N%22">McGinn N</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); 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South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22Pillinger+T%22">Pillinger T</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22McGuire+PK%22">McGuire PK</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).<br /><searchLink fieldCode="AU" term="%22McCutcheon+RA%22">McCutcheon RA</searchLink>; Department of Psychiatry (Mancini, Fanshawe, Varvari, Zauchenberger, Catalan, McGuire, McCutcheon), MRC Brain Network Dynamics Unit (Mancini), and Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging (Mancini), University of Oxford, Oxford, UK; TUNEUP, Oxford Health NHS Foundation Trust, Oxford, UK (Mancini, Varvari, Zauchenberger, McCutcheon); Department of Psychiatry, University of Geneva, Geneva (Latreche, McGinn); Oxford Health NHS Foundation Trust, Oxford, UK (Fanshawe, McGuire); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Catalan, Pillinger, McGuire, McCutcheon); Basurto University Hospital, OSI Bilbao-Basurto, Biobizkaia Health Research Institute, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Bilbao, Spain (Catalan); South London and Maudsley NHS Foundation Trust, London (Pillinger).
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