Genetic Alterations, Therapy Response, and Survival Among Patients With Triple-Negative Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.

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Title: Genetic Alterations, Therapy Response, and Survival Among Patients With Triple-Negative Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Authors: Richters L; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Gluz O; West German Study Group, Moenchengladbach, Germany.; Ev. Hospital Bethesda, Breast Center Niederrhein, Moenchengladbach, Germany.; Women's Clinic and Breast Center, University Clinics Cologne, Cologne, Germany., Weber-Lassalle N; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Christgen M; Institute of Pathology, Medical School Hannover, Hannover, Germany., Haverkamp H; Institute of Medical Statistics and Computational Biology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Now with Miltenyi Biomedicine GmbH, Bergisch Gladbach, Germany., Kuemmel S; West German Study Group, Moenchengladbach, Germany.; Interdisciplinary Breast Center, Kliniken Essen-Mitte, Evang. Hospital Essen-Mitte, Essen, Germany.; Department of Gynecology, Breast Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Kayali M; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Kates RE; West German Study Group, Moenchengladbach, Germany., Grischke EM; Women's Clinic, University Clinics Tübingen, Tübingen, Germany., Altmüller J; Cologne Center for Genomics, University of Cologne, Cologne, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Core Unit Genomics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany., Forstbauer H; Oncology Practice Network, Troisdorf, Germany., Thiele H; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Braun M; Interdisciplinary Breast Center, Rotkreuz-Clinics Munich, Munich, Germany., Warm M; Breast Center, Municipal Hospital Holweide, Cologne, Germany., Ossowski A; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Wuerstlein R; West German Study Group, Moenchengladbach, Germany.; Breast Center, Department of Obstetrics and Gynecology, Comprehensive Cancer Center Munich, University Hospital of Ludwig Maximilian University, Munich, Germany., Ernst C; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Graeser M; West German Study Group, Moenchengladbach, Germany.; Ev. Hospital Bethesda, Breast Center Niederrhein, Moenchengladbach, Germany.; Department of Gynecology, University Medical Center Hamburg, Hamburg, Germany., Linn SC; Department of Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Nitz U; West German Study Group, Moenchengladbach, Germany., Hauke J; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Kreipe HH; Institute of Pathology, Medical School Hannover, Hannover, Germany., Schmutzler RK; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Hahnen E; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Harbeck N; West German Study Group, Moenchengladbach, Germany.; Breast Center, Department of Obstetrics and Gynecology, Comprehensive Cancer Center Munich, University Hospital of Ludwig Maximilian University, Munich, Germany.
Source: JAMA network open [JAMA Netw Open] 2025 Feb 03; Vol. 8 (2), pp. e2461639. Date of Electronic Publication: 2025 Feb 03.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic Alterations, Therapy Response, and Survival Among Patients With Triple-Negative Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Richters+L%22">Richters L</searchLink>; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Gluz+O%22">Gluz O</searchLink>; West German Study Group, Moenchengladbach, Germany.; Ev. Hospital Bethesda, Breast Center Niederrhein, Moenchengladbach, Germany.; Women's Clinic and Breast Center, University Clinics Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Weber-Lassalle+N%22">Weber-Lassalle N</searchLink>; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Christgen+M%22">Christgen M</searchLink>; Institute of Pathology, Medical School Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Haverkamp+H%22">Haverkamp H</searchLink>; Institute of Medical Statistics and Computational Biology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Now with Miltenyi Biomedicine GmbH, Bergisch Gladbach, Germany.<br /><searchLink fieldCode="AU" term="%22Kuemmel+S%22">Kuemmel S</searchLink>; West German Study Group, Moenchengladbach, Germany.; Interdisciplinary Breast Center, Kliniken Essen-Mitte, Evang. Hospital Essen-Mitte, Essen, Germany.; Department of Gynecology, Breast Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kayali+M%22">Kayali M</searchLink>; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kates+RE%22">Kates RE</searchLink>; West German Study Group, Moenchengladbach, Germany.<br /><searchLink fieldCode="AU" term="%22Grischke+EM%22">Grischke EM</searchLink>; Women's Clinic, University Clinics Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Altmüller+J%22">Altmüller J</searchLink>; Cologne Center for Genomics, University of Cologne, Cologne, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Core Unit Genomics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Forstbauer+H%22">Forstbauer H</searchLink>; Oncology Practice Network, Troisdorf, Germany.<br /><searchLink fieldCode="AU" term="%22Thiele+H%22">Thiele H</searchLink>; Cologne Center for Genomics, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Braun+M%22">Braun M</searchLink>; Interdisciplinary Breast Center, Rotkreuz-Clinics Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Warm+M%22">Warm M</searchLink>; Breast Center, Municipal Hospital Holweide, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ossowski+A%22">Ossowski A</searchLink>; Cologne Center for Genomics, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Wuerstlein+R%22">Wuerstlein R</searchLink>; West German Study Group, Moenchengladbach, Germany.; Breast Center, Department of Obstetrics and Gynecology, Comprehensive Cancer Center Munich, University Hospital of Ludwig Maximilian University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ernst+C%22">Ernst C</searchLink>; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Graeser+M%22">Graeser M</searchLink>; West German Study Group, Moenchengladbach, Germany.; Ev. Hospital Bethesda, Breast Center Niederrhein, Moenchengladbach, Germany.; Department of Gynecology, University Medical Center Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Linn+SC%22">Linn SC</searchLink>; Department of Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nitz+U%22">Nitz U</searchLink>; West German Study Group, Moenchengladbach, Germany.<br /><searchLink fieldCode="AU" term="%22Hauke+J%22">Hauke J</searchLink>; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kreipe+HH%22">Kreipe HH</searchLink>; Institute of Pathology, Medical School Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Schmutzler+RK%22">Schmutzler RK</searchLink>; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hahnen+E%22">Hahnen E</searchLink>; Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Harbeck+N%22">Harbeck N</searchLink>; West German Study Group, Moenchengladbach, Germany.; Breast Center, Department of Obstetrics and Gynecology, Comprehensive Cancer Center Munich, University Hospital of Ludwig Maximilian University, Munich, Germany.
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