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Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patients.

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Title: Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patients.
Authors: Lin CC; Ataxia Center, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Fang KC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan., Balbo I; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Liang TY; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei 10002, Taiwan., Liu CW; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan., Liu WC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei 10002, Taiwan., Wang YM; Cerebellar Research Center, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan., Hung YL; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan., Yang KC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan., Geng SK; Department of Computer Science, Columbia University, New York, NY 10027, USA., Ni CL; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Driscoll CP; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Ruff DS; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Kumar A; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Amokrane N; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Desai N; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Faust PL; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Louis ED; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Kuo SH; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA., Pan MK; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei 10002, Taiwan.; Cerebellar Research Center, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 10638, Taiwan.
Source: Science translational medicine [Sci Transl Med] 2025 Feb 26; Vol. 17 (787), pp. eadk3922. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patients.
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  Data: <searchLink fieldCode="AU" term="%22Lin+CC%22">Lin CC</searchLink>; Ataxia Center, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Fang+KC%22">Fang KC</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.<br /><searchLink fieldCode="AU" term="%22Balbo+I%22">Balbo I</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Liang+TY%22">Liang TY</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei 10002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CW%22">Liu CW</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+WC%22">Liu WC</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei 10002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YM%22">Wang YM</searchLink>; Cerebellar Research Center, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+YL%22">Hung YL</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+KC%22">Yang KC</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.<br /><searchLink fieldCode="AU" term="%22Geng+SK%22">Geng SK</searchLink>; Department of Computer Science, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Ni+CL%22">Ni CL</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Driscoll+CP%22">Driscoll CP</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Ruff+DS%22">Ruff DS</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Amokrane+N%22">Amokrane N</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Desai+N%22">Desai N</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Faust+PL%22">Faust PL</searchLink>; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Louis+ED%22">Louis ED</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Kuo+SH%22">Kuo SH</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Pan+MK%22">Pan MK</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.; Molecular Imaging Center, National Taiwan University, Taipei 106038, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei 10002, Taiwan.; Cerebellar Research Center, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 10638, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Feb 26; Vol. 17 (787), pp. eadk3922. <i>Date of Electronic Publication: </i>2025 Feb 26.
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