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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors.

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Title: Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors.
Authors: Musiani D; INSERM U830, PSL Research University, Institut Curie, Paris, France., Yücel H; INSERM U830, PSL Research University, Institut Curie, Paris, France., Vallette M; INSERM U830, PSL Research University, Institut Curie, Paris, France., Angrisani A; Institut Curie, PSL Research University, Sorbonne Université, CNRS, UMR144 and UMR3664, 26 rue d'Ulm, 75005 Paris, France., El Botty R; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL Research University, Paris, France., Ouine B; Recombinant Protein Facility CNRS UMR144, Institut Curie, PSL Research University, Paris, France., Schintu N; INSERM U830, PSL Research University, Institut Curie, Paris, France., Adams C; INSERM U830, PSL Research University, Institut Curie, Paris, France., Chevalier M; INSERM U830, PSL Research University, Institut Curie, Paris, France., Heloise D; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL Research University, Paris, France., El Marjou A; Recombinant Protein Facility CNRS UMR144, Institut Curie, PSL Research University, Paris, France., Nemazanyy I; Platform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR 3633, Paris, France., Regairaz M; INSERM U830, PSL Research University, Institut Curie, Paris, France; Laboratoire de Biologie et Pharmacologie Appliquée, ENS-Paris-Saclay, CNRS UMR 8113, Université Paris-Saclay, 91190 Gif-sur-Yvette, France., Marangoni E; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL Research University, Paris, France., Fachinetti D; Institut Curie, PSL Research University, Sorbonne Université, CNRS, UMR144 and UMR3664, 26 rue d'Ulm, 75005 Paris, France., Ceccaldi R; INSERM U830, PSL Research University, Institut Curie, Paris, France. Electronic address: raphael.ceccaldi@curie.fr.
Source: Molecular cell [Mol Cell] 2025 Mar 20; Vol. 85 (6), pp. 1072-1084.e10. Date of Electronic Publication: 2025 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors.
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  Data: <searchLink fieldCode="AU" term="%22Musiani+D%22">Musiani D</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Yücel+H%22">Yücel H</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vallette+M%22">Vallette M</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Angrisani+A%22">Angrisani A</searchLink>; Institut Curie, PSL Research University, Sorbonne Université, CNRS, UMR144 and UMR3664, 26 rue d'Ulm, 75005 Paris, France.<br /><searchLink fieldCode="AU" term="%22El+Botty+R%22">El Botty R</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ouine+B%22">Ouine B</searchLink>; Recombinant Protein Facility CNRS UMR144, Institut Curie, PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Schintu+N%22">Schintu N</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Adams+C%22">Adams C</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Chevalier+M%22">Chevalier M</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Heloise+D%22">Heloise D</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22El+Marjou+A%22">El Marjou A</searchLink>; Recombinant Protein Facility CNRS UMR144, Institut Curie, PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Nemazanyy+I%22">Nemazanyy I</searchLink>; Platform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR 3633, Paris, France.<br /><searchLink fieldCode="AU" term="%22Regairaz+M%22">Regairaz M</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France; Laboratoire de Biologie et Pharmacologie Appliquée, ENS-Paris-Saclay, CNRS UMR 8113, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.<br /><searchLink fieldCode="AU" term="%22Marangoni+E%22">Marangoni E</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Fachinetti+D%22">Fachinetti D</searchLink>; Institut Curie, PSL Research University, Sorbonne Université, CNRS, UMR144 and UMR3664, 26 rue d'Ulm, 75005 Paris, France.<br /><searchLink fieldCode="AU" term="%22Ceccaldi+R%22">Ceccaldi R</searchLink>; INSERM U830, PSL Research University, Institut Curie, Paris, France. Electronic address: raphael.ceccaldi@curie.fr.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2025 Mar 20; Vol. 85 (6), pp. 1072-1084.e10. <i>Date of Electronic Publication: </i>2025 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9802571 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4164 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210972765%22">10972765 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cell <i>Subsets: </i>MEDLINE
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