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A Multitrait Open-Angle Glaucoma Polygenic Risk Score Stratifies Risk of Glaucoma Diagnosis and Severity in Eyes with Pseudoexfoliation.

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Title: A Multitrait Open-Angle Glaucoma Polygenic Risk Score Stratifies Risk of Glaucoma Diagnosis and Severity in Eyes with Pseudoexfoliation.
Authors: Kolovos A; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. Electronic address: antonia.kolovos@flinders.edu.au., Qassim A; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Hassall MM; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Marshall HN; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Schmidt J; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Nguyen TT; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., He W; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Mullany S; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Hollitt GL; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Berry EC; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Tang V; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Zhou T; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Lake S; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Mills R; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Landers J; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Casson RJ; Ophthalmic Research Laboratories, University of Adelaide, Adelaide Health and Medical Sciences Building, Adelaide, South Australia, Australia., Galanopoulos A; Department of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia., Graham SL; Faculty of Medicine, Health and Human Sciences, Ophthalmology and Vision Science, Macquarie University, Sydney, New South Wales, Australia., Schulz A; Faculty of Medicine, Health and Human Sciences, Ophthalmology and Vision Science, Macquarie University, Sydney, New South Wales, Australia., Healey PR; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Mitchell P; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Goldberg I; Department of Ophthalmology, University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia., Grigg J; Faculty of Medicine and Health, Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia., Ruddle J; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Mackey DA; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Western Australia, Australia., Burdon KP; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Hewitt AW; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Western Australia, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Seviiri M; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gharahkhani P; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Souzeau E; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia., Siggs OM; Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia., MacGregor S; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Craig JE; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.
Source: Ophthalmology [Ophthalmology] 2025 Aug; Vol. 132 (8), pp. 878-887. Date of Electronic Publication: 2025 Feb 24.
Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7802443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-4713 (Electronic) Linking ISSN: 01616420 NLM ISO Abbreviation: Ophthalmology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Multitrait Open-Angle Glaucoma Polygenic Risk Score Stratifies Risk of Glaucoma Diagnosis and Severity in Eyes with Pseudoexfoliation.
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  Data: <searchLink fieldCode="AU" term="%22Kolovos+A%22">Kolovos A</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. Electronic address: antonia.kolovos@flinders.edu.au.<br /><searchLink fieldCode="AU" term="%22Qassim+A%22">Qassim A</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Hassall+MM%22">Hassall MM</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Marshall+HN%22">Marshall HN</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Schmidt+J%22">Schmidt J</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+TT%22">Nguyen TT</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22He+W%22">He W</searchLink>; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Mullany+S%22">Mullany S</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Hollitt+GL%22">Hollitt GL</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Berry+EC%22">Berry EC</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Tang+V%22">Tang V</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Lake+S%22">Lake S</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Mills+R%22">Mills R</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Landers+J%22">Landers J</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Casson+RJ%22">Casson RJ</searchLink>; Ophthalmic Research Laboratories, University of Adelaide, Adelaide Health and Medical Sciences Building, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Galanopoulos+A%22">Galanopoulos A</searchLink>; Department of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Graham+SL%22">Graham SL</searchLink>; Faculty of Medicine, Health and Human Sciences, Ophthalmology and Vision Science, Macquarie University, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Schulz+A%22">Schulz A</searchLink>; Faculty of Medicine, Health and Human Sciences, Ophthalmology and Vision Science, Macquarie University, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Healey+PR%22">Healey PR</searchLink>; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Mitchell+P%22">Mitchell P</searchLink>; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Goldberg+I%22">Goldberg I</searchLink>; Department of Ophthalmology, University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Grigg+J%22">Grigg J</searchLink>; Faculty of Medicine and Health, Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Ruddle+J%22">Ruddle J</searchLink>; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Mackey+DA%22">Mackey DA</searchLink>; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Burdon+KP%22">Burdon KP</searchLink>; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.<br /><searchLink fieldCode="AU" term="%22Hewitt+AW%22">Hewitt AW</searchLink>; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Western Australia, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.<br /><searchLink fieldCode="AU" term="%22Seviiri+M%22">Seviiri M</searchLink>; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Gharahkhani+P%22">Gharahkhani P</searchLink>; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Souzeau+E%22">Souzeau E</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Siggs+OM%22">Siggs OM</searchLink>; Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22MacGregor+S%22">MacGregor S</searchLink>; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Craig+JE%22">Craig JE</searchLink>; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.
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  Data: <searchLink fieldCode="JN" term="%227802443%22">Ophthalmology</searchLink> [Ophthalmology] 2025 Aug; Vol. 132 (8), pp. 878-887. <i>Date of Electronic Publication: </i>2025 Feb 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802443 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1549-4713 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201616420%22">01616420 </searchLink><i>NLM ISO Abbreviation: </i>Ophthalmology <i>Subsets: </i>MEDLINE
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