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Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics.

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Title: Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics.
Authors: Rödström KEJ; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Eymsh B; Institute of Physiology, Kiel University, Kiel, Germany., Proks P; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Hayre MS; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Cordeiro S; Institute of Physiology, Kiel University, Kiel, Germany., Mendez-Otalvaro E; Computational Biomolecular Dynamics Group, Max Planck Institute, Göttingen, Germany., Madry C; Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Rowland A; Cerevance Ltd, Cambridge Science Park, Cambridge, UK., Kopec W; Computational Biomolecular Dynamics Group, Max Planck Institute, Göttingen, Germany.; Department of Chemistry, Queen Mary University of London, London, UK., Newstead S; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK., Baukrowitz T; Institute of Physiology, Kiel University, Kiel, Germany., Schewe M; Institute of Physiology, Kiel University, Kiel, Germany. m.schewe@physiologie.uni-kiel.de., Tucker SJ; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Jul; Vol. 32 (7), pp. 1167-1174. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: Cryo-EM structure of the human THIK-1 K2P K<superscript>+</superscript> channel reveals a lower Y gate regulated by lipids and anesthetics.
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  Data: <searchLink fieldCode="AU" term="%22Rödström+KEJ%22">Rödström KEJ</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Eymsh+B%22">Eymsh B</searchLink>; Institute of Physiology, Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Proks+P%22">Proks P</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hayre+MS%22">Hayre MS</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cordeiro+S%22">Cordeiro S</searchLink>; Institute of Physiology, Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Mendez-Otalvaro+E%22">Mendez-Otalvaro E</searchLink>; Computational Biomolecular Dynamics Group, Max Planck Institute, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Madry+C%22">Madry C</searchLink>; Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rowland+A%22">Rowland A</searchLink>; Cerevance Ltd, Cambridge Science Park, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kopec+W%22">Kopec W</searchLink>; Computational Biomolecular Dynamics Group, Max Planck Institute, Göttingen, Germany.; Department of Chemistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Newstead+S%22">Newstead S</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Baukrowitz+T%22">Baukrowitz T</searchLink>; Institute of Physiology, Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Schewe+M%22">Schewe M</searchLink>; Institute of Physiology, Kiel University, Kiel, Germany. m.schewe@physiologie.uni-kiel.de.<br /><searchLink fieldCode="AU" term="%22Tucker+SJ%22">Tucker SJ</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.
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