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Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation.

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Title: Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation.
Authors: Lin C; School of Pharmacy, National Taiwan University, Taipei, ROC., Hsu JL; School of Pharmacy, National Taiwan University, Taipei, ROC.; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan City, ROC.; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, ROC., Hsu YT; School of Pharmacy, National Taiwan University, Taipei, ROC., Fan KC; School of Pharmacy, National Taiwan University, Taipei, ROC., Wu SS; School of Pharmacy, National Taiwan University, Taipei, ROC., Lin MH; Department and Graduate Institute of Medical Microbiology, College of Medicine, National Taiwan University, Taipei, ROC., Guh JH; School of Pharmacy, National Taiwan University, Taipei, ROC., Yu CW; School of Pharmacy, National Taiwan University, Taipei, ROC.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2468355. Date of Electronic Publication: 2025 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation.
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  Data: <searchLink fieldCode="AU" term="%22Lin+C%22">Lin C</searchLink>; School of Pharmacy, National Taiwan University, Taipei, ROC.<br /><searchLink fieldCode="AU" term="%22Hsu+JL%22">Hsu JL</searchLink>; School of Pharmacy, National Taiwan University, Taipei, ROC.; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan City, ROC.; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, ROC.<br /><searchLink fieldCode="AU" term="%22Hsu+YT%22">Hsu YT</searchLink>; School of Pharmacy, National Taiwan University, Taipei, ROC.<br /><searchLink fieldCode="AU" term="%22Fan+KC%22">Fan KC</searchLink>; School of Pharmacy, National Taiwan University, Taipei, ROC.<br /><searchLink fieldCode="AU" term="%22Wu+SS%22">Wu SS</searchLink>; School of Pharmacy, National Taiwan University, Taipei, ROC.<br /><searchLink fieldCode="AU" term="%22Lin+MH%22">Lin MH</searchLink>; Department and Graduate Institute of Medical Microbiology, College of Medicine, National Taiwan University, Taipei, ROC.<br /><searchLink fieldCode="AU" term="%22Guh+JH%22">Guh JH</searchLink>; School of Pharmacy, National Taiwan University, Taipei, ROC.<br /><searchLink fieldCode="AU" term="%22Yu+CW%22">Yu CW</searchLink>; School of Pharmacy, National Taiwan University, Taipei, ROC.
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  Data: <searchLink fieldCode="JN" term="%22101150203%22">Journal of enzyme inhibition and medicinal chemistry</searchLink> [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2468355. <i>Date of Electronic Publication: </i>2025 Feb 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101150203 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-6374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214756366%22">14756366 </searchLink><i>NLM ISO Abbreviation: </i>J Enzyme Inhib Med Chem <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1080/14756366.2025.2468355
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      – Code: eng
        Text: English
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        StartPage: 2468355
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      – TitleFull: Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation.
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            NameFull: Lin C
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            NameFull: Hsu JL
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            NameFull: Lin MH
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            – D: 01
              M: 12
              Text: 2025 Dec
              Type: published
              Y: 2025
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              Value: 1475-6374
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              Value: 40
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