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Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.

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Title: Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.
Authors: Klawon DEJ; Department of Pathology, University of Chicago, Chicago, IL, USA., Pagane N; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Walker MT; Department of Pathology, University of Chicago, Chicago, IL, USA., Ganci NK; Department of Pathology, University of Chicago, Chicago, IL, USA., Miller CH; Department of Pathology, University of Chicago, Chicago, IL, USA.; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA., Gai E; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Rodriguez DM; Department of Pathology, University of Chicago, Chicago, IL, USA.; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA., Ryan-Payseur BK; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA., Duncombe RK; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Adams EJ; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Maienschein-Cline M; Research Informatics Core, Research Resources Center, University of Illinois Chicago, Chicago, IL, USA., Freitag NE; Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, IL, USA., Germain RN; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wong HS; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Savage PA; Department of Pathology, University of Chicago, Chicago, IL, USA.
Source: Science (New York, N.Y.) [Science] 2025 Mar 21; Vol. 387 (6740), pp. eadk3248. Date of Electronic Publication: 2025 Mar 21.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Klawon+DEJ%22">Klawon DEJ</searchLink>; Department of Pathology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pagane+N%22">Pagane N</searchLink>; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Walker+MT%22">Walker MT</searchLink>; Department of Pathology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Ganci+NK%22">Ganci NK</searchLink>; Department of Pathology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Miller+CH%22">Miller CH</searchLink>; Department of Pathology, University of Chicago, Chicago, IL, USA.; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Gai+E%22">Gai E</searchLink>; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+DM%22">Rodriguez DM</searchLink>; Department of Pathology, University of Chicago, Chicago, IL, USA.; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Ryan-Payseur+BK%22">Ryan-Payseur BK</searchLink>; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Duncombe+RK%22">Duncombe RK</searchLink>; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Adams+EJ%22">Adams EJ</searchLink>; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Maienschein-Cline+M%22">Maienschein-Cline M</searchLink>; Research Informatics Core, Research Resources Center, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Freitag+NE%22">Freitag NE</searchLink>; Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Germain+RN%22">Germain RN</searchLink>; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wong+HS%22">Wong HS</searchLink>; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Savage+PA%22">Savage PA</searchLink>; Department of Pathology, University of Chicago, Chicago, IL, USA.
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