Akt2 inhibition alleviates temporomandibular joint osteoarthritis by preventing subchondral bone loss.

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Title: Akt2 inhibition alleviates temporomandibular joint osteoarthritis by preventing subchondral bone loss.
Authors: Feng SY; Center for TMD & Orofacial Pain, Peking University School and Hospital of Stomatology, No. 22 Zhong Guan Cun South Ave, Beijing, 100081, China.; National Center for Stomatology & National Clinical Research Center for Oral Diseases, Beijing, China.; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; Beijing Key Laboratory of Digital Stomatology, Beijing, China., Cao MN; Center for TMD & Orofacial Pain, Peking University School and Hospital of Stomatology, No. 22 Zhong Guan Cun South Ave, Beijing, 100081, China.; Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China.; National Center for Stomatology & National Clinical Research Center for Oral Diseases, Beijing, China.; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; Beijing Key Laboratory of Digital Stomatology, Beijing, China., Gao CC; Center for TMD & Orofacial Pain, Peking University School and Hospital of Stomatology, No. 22 Zhong Guan Cun South Ave, Beijing, 100081, China.; Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China.; National Center for Stomatology & National Clinical Research Center for Oral Diseases, Beijing, China.; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; Beijing Key Laboratory of Digital Stomatology, Beijing, China., Li YX; Center for TMD & Orofacial Pain, Peking University School and Hospital of Stomatology, No. 22 Zhong Guan Cun South Ave, Beijing, 100081, China.; Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China.; National Center for Stomatology & National Clinical Research Center for Oral Diseases, Beijing, China.; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; Beijing Key Laboratory of Digital Stomatology, Beijing, China., Lei J; Center for TMD & Orofacial Pain, Peking University School and Hospital of Stomatology, No. 22 Zhong Guan Cun South Ave, Beijing, 100081, China. leijierebecca1986@163.com.; National Center for Stomatology & National Clinical Research Center for Oral Diseases, Beijing, China. leijierebecca1986@163.com.; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. leijierebecca1986@163.com.; Beijing Key Laboratory of Digital Stomatology, Beijing, China. leijierebecca1986@163.com., Fu KY; Center for TMD & Orofacial Pain, Peking University School and Hospital of Stomatology, No. 22 Zhong Guan Cun South Ave, Beijing, 100081, China. kqkyfu@bjmu.edu.cn.; National Center for Stomatology & National Clinical Research Center for Oral Diseases, Beijing, China. kqkyfu@bjmu.edu.cn.; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. kqkyfu@bjmu.edu.cn.; Beijing Key Laboratory of Digital Stomatology, Beijing, China. kqkyfu@bjmu.edu.cn.
Source: Arthritis research & therapy [Arthritis Res Ther] 2025 Feb 27; Vol. 27 (1), pp. 43. Date of Electronic Publication: 2025 Feb 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1478-6362
DOI:10.1186/s13075-025-03506-x