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Unraveling the molecular basis of substrate specificity and halogen activation in vanadium-dependent haloperoxidases.

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Title: Unraveling the molecular basis of substrate specificity and halogen activation in vanadium-dependent haloperoxidases.
Authors: Zeides P; Biomimetic Catalysis, Catalysis Research Center, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany.; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany., Bellmann-Sickert K; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany., Zhang R; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany.; Organic Chemistry, Saarland University, Saarbruecken, Germany., Seel CJ; Biomimetic Catalysis, Catalysis Research Center, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany., Most V; Faculty of Medicine, Institute for Drug Discovery, Leipzig University, Leipzig, Germany., Schoeder CT; Faculty of Medicine, Institute for Drug Discovery, Leipzig University, Leipzig, Germany., Groll M; Department of Bioscience, Center for Protein Assemblies, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany., Gulder T; Biomimetic Catalysis, Catalysis Research Center, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany. tanja.gulder@uni-saarland.de.; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany. tanja.gulder@uni-saarland.de.; Organic Chemistry, Saarland University, Saarbruecken, Germany. tanja.gulder@uni-saarland.de.; Synthesis of Natural-Product Derived Drugs, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany. tanja.gulder@uni-saarland.de.
Source: Nature communications [Nat Commun] 2025 Feb 28; Vol. 16 (1), pp. 2083. Date of Electronic Publication: 2025 Feb 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zeides+P%22">Zeides P</searchLink>; Biomimetic Catalysis, Catalysis Research Center, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany.; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Bellmann-Sickert+K%22">Bellmann-Sickert K</searchLink>; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany.; Organic Chemistry, Saarland University, Saarbruecken, Germany.<br /><searchLink fieldCode="AU" term="%22Seel+CJ%22">Seel CJ</searchLink>; Biomimetic Catalysis, Catalysis Research Center, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Most+V%22">Most V</searchLink>; Faculty of Medicine, Institute for Drug Discovery, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schoeder+CT%22">Schoeder CT</searchLink>; Faculty of Medicine, Institute for Drug Discovery, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Groll+M%22">Groll M</searchLink>; Department of Bioscience, Center for Protein Assemblies, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Gulder+T%22">Gulder T</searchLink>; Biomimetic Catalysis, Catalysis Research Center, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany. tanja.gulder@uni-saarland.de.; Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, Leipzig University, Leipzig, Germany. tanja.gulder@uni-saarland.de.; Organic Chemistry, Saarland University, Saarbruecken, Germany. tanja.gulder@uni-saarland.de.; Synthesis of Natural-Product Derived Drugs, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany. tanja.gulder@uni-saarland.de.
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