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The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma.

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Title: The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma.
Authors: Berry D; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada., Moldoveanu D; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Rajkumar S; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada., Lajoie M; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada., Lin T; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada., Tchelougou D; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada., Sakthivel S; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada., Sharon I; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada., Bernard A; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada., Pelletier S; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada., Ripstein Y; Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0W2, Canada., Spatz A; McGill University Health Centre, Montréal, QC H4A 3J1, Canada; Lady Davis Institute, McGill University, Montréal, QC H3T 1E1, Canada., Miller WH; Lady Davis Institute, McGill University, Montréal, QC H3T 1E1, Canada., Jamal R; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada., Lapointe R; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Neurological Institute and Hospital, Montréal, QC H3A 2B4, Canada., Mes-Masson AM; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada., Petrecca K; Montreal Neurological Institute and Hospital, Montréal, QC H3A 2B4, Canada., Meguerditchian AN; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Richardson K; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Wang B; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Chergui M; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Guiot MC; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Watters K; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Stagg J; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada., Schmeing TM; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada., Rodier F; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada., Turcotte S; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada., Mihalcioiu C; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Meterissian S; McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Watson IR; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada; McGill University Health Centre, Montréal, QC H4A 3J1, Canada. Electronic address: ian.watson2@mcgill.ca.
Source: Cell reports [Cell Rep] 2025 Mar 25; Vol. 44 (3), pp. 115365. Date of Electronic Publication: 2025 Mar 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma.
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  Data: <searchLink fieldCode="AU" term="%22Berry+D%22">Berry D</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Moldoveanu+D%22">Moldoveanu D</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Rajkumar+S%22">Rajkumar S</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Lajoie+M%22">Lajoie M</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+T%22">Lin T</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Tchelougou+D%22">Tchelougou D</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Sakthivel+S%22">Sakthivel S</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Sharon+I%22">Sharon I</searchLink>; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Bernard+A%22">Bernard A</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Pelletier+S%22">Pelletier S</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Ripstein+Y%22">Ripstein Y</searchLink>; Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0W2, Canada.<br /><searchLink fieldCode="AU" term="%22Spatz+A%22">Spatz A</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada; Lady Davis Institute, McGill University, Montréal, QC H3T 1E1, Canada.<br /><searchLink fieldCode="AU" term="%22Miller+WH%22">Miller WH</searchLink>; Lady Davis Institute, McGill University, Montréal, QC H3T 1E1, Canada.<br /><searchLink fieldCode="AU" term="%22Jamal+R%22">Jamal R</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Lapointe+R%22">Lapointe R</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Neurological Institute and Hospital, Montréal, QC H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Mes-Masson+AM%22">Mes-Masson AM</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Petrecca+K%22">Petrecca K</searchLink>; Montreal Neurological Institute and Hospital, Montréal, QC H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Meguerditchian+AN%22">Meguerditchian AN</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Richardson+K%22">Richardson K</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Chergui+M%22">Chergui M</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Guiot+MC%22">Guiot MC</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Watters+K%22">Watters K</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Stagg+J%22">Stagg J</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Schmeing+TM%22">Schmeing TM</searchLink>; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Rodier+F%22">Rodier F</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Turcotte+S%22">Turcotte S</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Mihalcioiu+C%22">Mihalcioiu C</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Meterissian+S%22">Meterissian S</searchLink>; McGill University Health Centre, Montréal, QC H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Watson+IR%22">Watson IR</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada; McGill University Health Centre, Montréal, QC H4A 3J1, Canada. Electronic address: ian.watson2@mcgill.ca.
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