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Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.

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Title: Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.
Authors: Tiwari A; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Paithane U; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Friedlein J; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Tashiro K; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Department of Urology, Jikei University School of Medicine, Tokyo, Japan., Saulnier O; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Barbosa K; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Trinh Q; Adaptive Oncology, Ontario Institute for Cancer Research, Toronto, ON, Canada., Hall B; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Saha S; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Soni A; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Nakashima T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan., Bobkov A; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Fujimoto LM; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Murad R; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Maurya S; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Saraswat M; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Sarmashghi S; Department of Medical Oncology and Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lange JT; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; ChEM-H, Stanford University, Stanford, CA, USA., Wu S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; ChEM-H, Stanford University, Stanford, CA, USA.; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Masihi MB; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Ghosh S; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Hemmati G; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Chapman O; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, San Diego, CA, USA., Hendrikse L; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., James B; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Luebeck J; Department of Computer Science, University of California San Diego, La Jolla, CA., Eisemann T; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Tzaridis T; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Rohila D; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Leary R; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Varshney J; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Konety B; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Urology, University of Minnesota, Minneapolis, MN, USA.; Rush Medical College, Chicago, IL, USA.; Allina Health Cancer Institute, MN, USA., Dehm SM; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Urology, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Kawakami Y; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Beroukhim R; Department of Medical Oncology and Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Largaespada DA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Stein L; Adaptive Oncology, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON Canada., Chavez L; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, San Diego, CA, USA.; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital and Healthcare Center, San Diego, CA, USA., Suzuki H; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan., Weiss WA; Departments of Neurology, Pediatrics, and Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Zhao J; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Deshpande A; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Wechsler-Reya RJ; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Taylor MD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Baylor College of Medicine., Bagchi A; Cancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Feb 22. Date of Electronic Publication: 2025 Feb 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.
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