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24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation.

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Title: 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation.
Authors: Zhu C; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Boucheron N; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Al-Rubaye O; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Chung BK; Department of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway., Thorbjørnsen LW; Department of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway., Köcher T; Vienna BioCenter Core Facilities, Metabolomics, Vienna BioCenter, Vienna, Austria., Schuster M; Biomedical Sequencing Facility, Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Claudel T; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Halilbasic E; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Kunczer V; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Muscate F; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany., Cavanagh LL; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Waltenberger D; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Lercher A; Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Ohradanova-Repic A; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Schatzlmaier P; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Stojakovic T; Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Bergthaler A; Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Stockinger H; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Huber S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bock C; Biomedical Sequencing Facility, Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kenner L; Division of Experimental and Translational Pathology, Department of Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, Department for Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Karlsen TH; Department of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway., Ellmeier W; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria michael.trauner@meduniwien.ac.at wilfried.ellmeier@meduniwien.ac.at., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria michael.trauner@meduniwien.ac.at wilfried.ellmeier@meduniwien.ac.at.
Source: Gut [Gut] 2025 Jun 06; Vol. 74 (7), pp. 1079-1093. Date of Electronic Publication: 2025 Jun 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T<subscript>H</subscript>17 pathogenicity and transdifferentiation.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+C%22">Zhu C</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Boucheron+N%22">Boucheron N</searchLink>; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Al-Rubaye+O%22">Al-Rubaye O</searchLink>; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Chung+BK%22">Chung BK</searchLink>; Department of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Thorbjørnsen+LW%22">Thorbjørnsen LW</searchLink>; Department of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Köcher+T%22">Köcher T</searchLink>; Vienna BioCenter Core Facilities, Metabolomics, Vienna BioCenter, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schuster+M%22">Schuster M</searchLink>; Biomedical Sequencing Facility, Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Claudel+T%22">Claudel T</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Halilbasic+E%22">Halilbasic E</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kunczer+V%22">Kunczer V</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Muscate+F%22">Muscate F</searchLink>; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Cavanagh+LL%22">Cavanagh LL</searchLink>; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Waltenberger+D%22">Waltenberger D</searchLink>; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lercher+A%22">Lercher A</searchLink>; Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Ohradanova-Repic+A%22">Ohradanova-Repic A</searchLink>; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schatzlmaier+P%22">Schatzlmaier P</searchLink>; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Stojakovic+T%22">Stojakovic T</searchLink>; Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Scharnagl+H%22">Scharnagl H</searchLink>; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Bergthaler+A%22">Bergthaler A</searchLink>; Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Stockinger+H%22">Stockinger H</searchLink>; Institute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Huber+S%22">Huber S</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bock+C%22">Bock C</searchLink>; Biomedical Sequencing Facility, Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kenner+L%22">Kenner L</searchLink>; Division of Experimental and Translational Pathology, Department of Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, Department for Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Karlsen+TH%22">Karlsen TH</searchLink>; Department of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Ellmeier+W%22">Ellmeier W</searchLink>; Institute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria michael.trauner@meduniwien.ac.at wilfried.ellmeier@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Trauner+M%22">Trauner M</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria michael.trauner@meduniwien.ac.at wilfried.ellmeier@meduniwien.ac.at.
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  Data: <searchLink fieldCode="JN" term="%222985108R%22">Gut</searchLink> [Gut] 2025 Jun 06; Vol. 74 (7), pp. 1079-1093. <i>Date of Electronic Publication: </i>2025 Jun 06.
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