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Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.

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Title: Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.
Authors: Henry A; Institute of Cardiovascular Science, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK., Mo X; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Finan C; Institute of Cardiovascular Science, University College London, London, UK., Chaffin MD; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Speed D; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Issa H; Institute of Health Informatics, University College London, London, UK., Denaxas S; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK, London, UK.; British Heart Foundation Data Science Centre, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK., Ware JS; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Hammersmith Hospital, Imperial College Hospitals NHS Trust, London, UK., Zheng SL; National Heart & Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Malarstig A; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Gratton J; Institute of Cardiovascular Science, University College London, London, UK., Bond I; Institute of Cardiovascular Science, University College London, London, UK., Roselli C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Miller D; Division of Biosciences, University College London, London, UK., Chopade S; Institute of Cardiovascular Science, University College London, London, UK., Schmidt AF; Institute of Cardiovascular Science, University College London, London, UK.; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Abner E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Adams L; Geisinger Health System, Danville, PA, USA., Andersson C; Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark.; National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA., Aragam KG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Ärnlöv J; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Sciences, Dalarna University, Falun, Sweden., Asselin G; Montreal Heart Institute, Montreal, Quebec, Canada., Raja AA; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Backman JD; Analytical Genetics, Regeneron Genetics Center, Tarrytown, NY, USA., Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Biddinger KJ; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Biggs ML; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Bloom HL; Department of Medicine, Division of Cardiology, Emory University Medical Center, Atlanta, GA, USA., Boersma E; Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Brandimarto J; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brown MR; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Buckbinder L; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Bundgaard H; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen X; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., Czuba T; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden., de Denus S; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada., Dehghan A; MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Doney AS; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Dudley SC; Department of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis, MN, USA., Engström G; Department of Clinical Sciences, Lund University, Malmö, Sweden., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Deparment of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark., Esko T; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Farber-Eger EH; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Finer S; Centre for Primary Care and Public Health, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Ford I; Robertson Center for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Ghasemi S; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Ghouse J; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gottdiener JS; Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA., Gross S; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Guðbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Gui H; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA., Gutmann R; Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Hägg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Haggerty CM; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Hedman ÅK; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Helgadottir A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Hemingway H; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK, London, UK., Hillege H; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Hyde CL; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Aagaard Jensen B; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, the Netherlands., Kardys I; Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Karra R; Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA., Kavousi M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Kizer JR; Cardiology Section, San Francisco Veterans Affairs Health System, and Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Køber L; Department of Cardiology, Nordsjaellands Hospital, Copenhagen, Denmark., Koekemoer A; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kuchenbaecker K; Division of Psychiatry, University College London, London, UK.; UCL Genetics Institute, University College London, London, UK., Lai YP; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Lanfear D; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.; Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA., Langenberg C; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.; Computational Medicine, Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, Berlin, Germany.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lin H; National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lindgren CM; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Liu PP; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.; Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada., London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA., Lowery BD; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Magnusson P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Margulies KB; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Marston NA; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA., Martin H; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden., Mordi IR; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Morley MP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Morrison AC; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA., Morton L; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Nagle MW; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Niessner A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Niiranen T; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.; National Institute for Health and Welfare, Helsinki, Finland., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands., Nowak C; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden., O'Donoghue ML; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Owens AT; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Palmer CNA; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton, Ontario, Canada., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Perola M; National Institute for Health and Welfare, Helsinki, Finland., Pigeyre M; Population Health Research Institute, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Romaine SPR; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Rotter JI; The Institute for Translational Genomics and Population Sciences, Harbor-UCLA Medical Center, Torrance, CA, USA.; Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.; Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA., Ruff CT; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA., Sabatine MS; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA., Sallah N; Institute of Health Informatics, University College London, London, UK., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Sattar N; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Shalaby AA; Department of Medicine, Division of Cardiology, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA., Shekhar A; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Smith NL; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Veterans Affairs Office of Research & Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Srinivasan S; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland., Sveinbjörnsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Svensson P; Department of Cardiology, Söderjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education-Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Tammesoo ML; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Teumer A; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thorgeirsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Internal Medicine, Division of Cardiology, National University Hospital of Iceland, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland., Torp-Pedersen C; Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark., Tragante V; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Ullum H; Statens Serum Institut, Copenhagen, Denmark., van der Harst P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., van Heel D; Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK., van Setten J; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., van Vugt M; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Veluchamy A; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Verschuuren M; Department Life Course and Health, Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Vissing CR; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Völker U; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Voors AA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Wallentin L; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden., Wang Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Weeke PE; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA., Williams LK; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA., Yang Y; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Yu B; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA., Zannad F; Université de Lorraine, CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Vandoeuvre Lès Nancy, France., Zheng C; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Asselbergs FW; Institute of Health Informatics, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Cappola TP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dubé MP; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Dunn ME; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Lang CC; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Shah S; Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.; Duke Clinical Research Institute, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA., Vasan RS; National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA., Smith JG; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Shah S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Cambridge, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hingorani AD; Institute of Cardiovascular Science, University College London, London, UK., Wells Q; Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, USA., Lumbers RT; Institute of Health Informatics, University College London, London, UK. t.lumbers@ucl.ac.uk.; Health Data Research UK, London, UK. t.lumbers@ucl.ac.uk.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK. t.lumbers@ucl.ac.uk.
Corporate Authors: Genes & Health Research Team, Estonian Biobank Research Team, DBDS Genomic Consortium, HERMES Consortium
Source: Nature genetics [Nat Genet] 2025 Apr; Vol. 57 (4), pp. 815-828. Date of Electronic Publication: 2025 Mar 04.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.
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Institute of Health Informatics, University College London, London, UK.; Health Data Research UK, London, UK.; British Heart Foundation Data Science Centre, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ware+JS%22">Ware JS</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Hammersmith Hospital, Imperial College Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Zheng+SL%22">Zheng SL</searchLink>; National Heart & Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Malarstig+A%22">Malarstig A</searchLink>; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.; Pfizer Worldwide Research & Development, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gratton+J%22">Gratton J</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bond+I%22">Bond I</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Roselli+C%22">Roselli C</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Miller+D%22">Miller D</searchLink>; Division of Biosciences, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chopade+S%22">Chopade S</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schmidt+AF%22">Schmidt AF</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Abner+E%22">Abner E</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Adams+L%22">Adams L</searchLink>; Geisinger Health System, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Andersson+C%22">Andersson C</searchLink>; Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark.; National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aragam+KG%22">Aragam KG</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ärnlöv+J%22">Ärnlöv J</searchLink>; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Sciences, Dalarna University, Falun, Sweden.<br /><searchLink fieldCode="AU" term="%22Asselin+G%22">Asselin G</searchLink>; Montreal Heart Institute, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Raja+AA%22">Raja AA</searchLink>; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Backman+JD%22">Backman JD</searchLink>; Analytical Genetics, Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bartz+TM%22">Bartz TM</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Biddinger+KJ%22">Biddinger KJ</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Biggs+ML%22">Biggs ML</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bloom+HL%22">Bloom HL</searchLink>; Department of Medicine, Division of Cardiology, Emory University Medical Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Boersma+E%22">Boersma E</searchLink>; Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Brandimarto+J%22">Brandimarto J</searchLink>; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+MR%22">Brown MR</searchLink>; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Brunak+S%22">Brunak S</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bruun+MT%22">Bruun MT</searchLink>; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Buckbinder+L%22">Buckbinder L</searchLink>; Pfizer Worldwide Research & Development, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bundgaard+H%22">Bundgaard H</searchLink>; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Carey+DJ%22">Carey DJ</searchLink>; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chasman+DI%22">Chasman DI</searchLink>; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Pfizer Worldwide Research & Development, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cook+JP%22">Cook JP</searchLink>; Department of Biostatistics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Czuba+T%22">Czuba T</searchLink>; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22de+Denus+S%22">de Denus S</searchLink>; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Dehghan+A%22">Dehghan A</searchLink>; MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Delgado+GE%22">Delgado GE</searchLink>; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Doney+AS%22">Doney AS</searchLink>; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Dörr+M%22">Dörr M</searchLink>; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Dowsett+J%22">Dowsett J</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Dudley+SC%22">Dudley SC</searchLink>; Department of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Engström+G%22">Engström G</searchLink>; Department of Clinical Sciences, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Erikstrup+C%22">Erikstrup C</searchLink>; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Deparment of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Esko+T%22">Esko T</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Farber-Eger+EH%22">Farber-Eger EH</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Felix+SB%22">Felix SB</searchLink>; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Finer+S%22">Finer S</searchLink>; Centre for Primary Care and Public Health, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ford+I%22">Ford I</searchLink>; Robertson Center for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ghanbari+M%22">Ghanbari M</searchLink>; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ghasemi+S%22">Ghasemi S</searchLink>; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Ghouse+J%22">Ghouse J</searchLink>; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Giedraitis+V%22">Giedraitis V</searchLink>; Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Giulianini+F%22">Giulianini F</searchLink>; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gottdiener+JS%22">Gottdiener JS</searchLink>; Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gross+S%22">Gross S</searchLink>; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Guðbjartsson+DF%22">Guðbjartsson DF</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gui+H%22">Gui H</searchLink>; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gutmann+R%22">Gutmann R</searchLink>; Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Hägg+S%22">Hägg S</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Haggerty+CM%22">Haggerty CM</searchLink>; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hedman+ÅK%22">Hedman ÅK</searchLink>; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Helgadottir+A%22">Helgadottir A</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Hemingway+H%22">Hemingway H</searchLink>; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK, London, UK.<br /><searchLink fieldCode="AU" term="%22Hillege+H%22">Hillege H</searchLink>; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hyde+CL%22">Hyde CL</searchLink>; Pfizer Worldwide Research & Development, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aagaard+Jensen+B%22">Aagaard Jensen B</searchLink>; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Jukema+JW%22">Jukema JW</searchLink>; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kardys+I%22">Kardys I</searchLink>; Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Karra+R%22">Karra R</searchLink>; Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kavousi+M%22">Kavousi M</searchLink>; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kizer+JR%22">Kizer JR</searchLink>; Cardiology Section, San Francisco Veterans Affairs Health System, and Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kleber+ME%22">Kleber ME</searchLink>; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Køber+L%22">Køber L</searchLink>; Department of Cardiology, Nordsjaellands Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Koekemoer+A%22">Koekemoer A</searchLink>; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Kuchenbaecker+K%22">Kuchenbaecker K</searchLink>; Division of Psychiatry, University College London, London, UK.; UCL Genetics Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lai+YP%22">Lai YP</searchLink>; Pfizer Worldwide Research & Development, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lanfear+D%22">Lanfear D</searchLink>; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.; Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Langenberg+C%22">Langenberg C</searchLink>; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.; Computational Medicine, Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, Berlin, Germany.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lind+L%22">Lind L</searchLink>; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Lindgren+CM%22">Lindgren CM</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+PP%22">Liu PP</searchLink>; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.; Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22London+B%22">London B</searchLink>; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Lowery+BD%22">Lowery BD</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Luan+J%22">Luan J</searchLink>; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lubitz+SA%22">Lubitz SA</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Magnusson+P%22">Magnusson P</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Margulies+KB%22">Margulies KB</searchLink>; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Marston+NA%22">Marston NA</searchLink>; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Martin+H%22">Martin H</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22März+W%22">März W</searchLink>; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Melander+O%22">Melander O</searchLink>; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Mordi+IR%22">Mordi IR</searchLink>; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Morley+MP%22">Morley MP</searchLink>; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Morris+AP%22">Morris AP</searchLink>; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Morrison+AC%22">Morrison AC</searchLink>; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Morton+L%22">Morton L</searchLink>; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nagle+MW%22">Nagle MW</searchLink>; Pfizer Worldwide Research & Development, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+CP%22">Nelson CP</searchLink>; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Niessner+A%22">Niessner A</searchLink>; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Niiranen+T%22">Niiranen T</searchLink>; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.; National Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Noordam+R%22">Noordam R</searchLink>; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nowak+C%22">Nowak C</searchLink>; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22O'Donoghue+ML%22">O'Donoghue ML</searchLink>; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ostrowski+SR%22">Ostrowski SR</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Owens+AT%22">Owens AT</searchLink>; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Palmer+CNA%22">Palmer CNA</searchLink>; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Paré+G%22">Paré G</searchLink>; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pedersen+OB%22">Pedersen OB</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Perola+M%22">Perola M</searchLink>; National Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Pigeyre+M%22">Pigeyre M</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Rice+KM%22">Rice KM</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ridker+PM%22">Ridker PM</searchLink>; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Romaine+SPR%22">Romaine SPR</searchLink>; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Harbor-UCLA Medical Center, Torrance, CA, USA.; Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.; Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ruff+CT%22">Ruff CT</searchLink>; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sabatine+MS%22">Sabatine MS</searchLink>; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sallah+N%22">Sallah N</searchLink>; Institute of Health Informatics, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Salomaa+V%22">Salomaa V</searchLink>; National Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sattar+N%22">Sattar N</searchLink>; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Shalaby+AA%22">Shalaby AA</searchLink>; Department of Medicine, Division of Cardiology, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shekhar+A%22">Shekhar A</searchLink>; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smelser+DT%22">Smelser DT</searchLink>; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+NL%22">Smith NL</searchLink>; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Veterans Affairs Office of Research & Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sørensen+E%22">Sørensen E</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Srinivasan+S%22">Srinivasan S</searchLink>; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Sveinbjörnsson+G%22">Sveinbjörnsson G</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Svensson+P%22">Svensson P</searchLink>; Department of Cardiology, Söderjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education-Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Tammesoo+ML%22">Tammesoo ML</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Tardif+JC%22">Tardif JC</searchLink>; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Teder-Laving+M%22">Teder-Laving M</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Teumer+A%22">Teumer A</searchLink>; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Thorgeirsson+G%22">Thorgeirsson G</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Internal Medicine, Division of Cardiology, National University Hospital of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Thorsteinsdottir+U%22">Thorsteinsdottir U</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Torp-Pedersen+C%22">Torp-Pedersen C</searchLink>; Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Tragante+V%22">Tragante V</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Trompet+S%22">Trompet S</searchLink>; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Uitterlinden+AG%22">Uitterlinden AG</searchLink>; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ullum+H%22">Ullum H</searchLink>; Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22van+der+Harst+P%22">van der Harst P</searchLink>; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Heel+D%22">van Heel D</searchLink>; Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22van+Setten+J%22">van Setten J</searchLink>; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Vugt+M%22">van Vugt M</searchLink>; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Veluchamy+A%22">Veluchamy A</searchLink>; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Verschuuren+M%22">Verschuuren M</searchLink>; Department Life Course and Health, Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verweij+N%22">Verweij N</searchLink>; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vissing+CR%22">Vissing CR</searchLink>; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Völker+U%22">Völker U</searchLink>; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Voors+AA%22">Voors AA</searchLink>; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wallentin+L%22">Wallentin L</searchLink>; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Weeke+PE%22">Weeke PE</searchLink>; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Wiggins+KL%22">Wiggins KL</searchLink>; Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Williams+LK%22">Williams LK</searchLink>; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+B%22">Yu B</searchLink>; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zannad+F%22">Zannad F</searchLink>; Université de Lorraine, CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Vandoeuvre Lès Nancy, France.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Asselbergs+FW%22">Asselbergs FW</searchLink>; Institute of Health Informatics, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cappola+TP%22">Cappola TP</searchLink>; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dubé+MP%22">Dubé MP</searchLink>; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Dunn+ME%22">Dunn ME</searchLink>; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lang+CC%22">Lang CC</searchLink>; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Samani+NJ%22">Samani NJ</searchLink>; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Shah+S%22">Shah S</searchLink>; Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.; Duke Clinical Research Institute, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Vasan+RS%22">Vasan RS</searchLink>; National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JG%22">Smith JG</searchLink>; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Holm+H%22">Holm H</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Shah+S%22">Shah S</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Ellinor+PT%22">Ellinor PT</searchLink>; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Cambridge, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hingorani+AD%22">Hingorani AD</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wells+Q%22">Wells Q</searchLink>; Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lumbers+RT%22">Lumbers RT</searchLink>; Institute of Health Informatics, University College London, London, UK. t.lumbers@ucl.ac.uk.; Health Data Research UK, London, UK. t.lumbers@ucl.ac.uk.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK. t.lumbers@ucl.ac.uk.
– Name: AuthorCorporate
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  Data: <searchLink fieldCode="CA" term="%22Genes+%26+Health+Research+Team%22">Genes & Health Research Team</searchLink><br /><searchLink fieldCode="CA" term="%22Estonian+Biobank+Research+Team%22">Estonian Biobank Research Team</searchLink><br /><searchLink fieldCode="CA" term="%22DBDS+Genomic+Consortium%22">DBDS Genomic Consortium</searchLink><br /><searchLink fieldCode="CA" term="%22HERMES+Consortium%22">HERMES Consortium</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2025 Apr; Vol. 57 (4), pp. 815-828. <i>Date of Electronic Publication: </i>2025 Mar 04.
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  Data: Journal Article; Meta-Analysis
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41588-024-02064-3
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      – TitleFull: Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.
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          Dates:
            – D: 01
              M: 04
              Text: 2025 Apr
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 57
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1