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A deep-learning retinal aging biomarker for cognitive decline and incident dementia.

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Title: A deep-learning retinal aging biomarker for cognitive decline and incident dementia.
Authors: Sim MA; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.; Department of Anesthesia, National University Health System and National University of Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore., Tham YC; Centre for Innovation and Precision Eye Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Nusinovici S; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Quek TC; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Yu M; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Xue CC; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Chee ML; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Peng QS; Centre for Innovation and Precision Eye Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan ESJ; National University Heart Centre, National University Hospital, Singapore, Singapore., Chan SP; National University Heart Centre, National University Hospital, Singapore, Singapore., Cai Y; Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Chong EJY; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore., Tan BY; St Luke's Hospital, Singapore, Singapore., Venketasubramanian N; Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore., Hilal S; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Lai MKP; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore., Choi H; Cardiovascular Metabolic Disease Translational Research Program, National University of Singapore, Singapore, Singapore., Richards AM; Cardiovascular Metabolic Disease Translational Research Program, National University of Singapore, Singapore, Singapore.; Christchurch Heart Institute, University of Otago, Dunedin North, Dunedin, New Zealand., Cheng CY; Centre for Innovation and Precision Eye Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Chen CLH; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Mar; Vol. 21 (3), pp. e14601.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A deep-learning retinal aging biomarker for cognitive decline and incident dementia.
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  Data: <searchLink fieldCode="AU" term="%22Sim+MA%22">Sim MA</searchLink>; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.; Department of Anesthesia, National University Health System and National University of Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tham+YC%22">Tham YC</searchLink>; Centre for Innovation and Precision Eye Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nusinovici+S%22">Nusinovici S</searchLink>; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Quek+TC%22">Quek TC</searchLink>; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+M%22">Yu M</searchLink>; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Xue+CC%22">Xue CC</searchLink>; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chee+ML%22">Chee ML</searchLink>; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Peng+QS%22">Peng QS</searchLink>; Centre for Innovation and Precision Eye Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+ESJ%22">Tan ESJ</searchLink>; National University Heart Centre, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+SP%22">Chan SP</searchLink>; National University Heart Centre, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Chong+EJY%22">Chong EJY</searchLink>; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+BY%22">Tan BY</searchLink>; St Luke's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Venketasubramanian+N%22">Venketasubramanian N</searchLink>; Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hilal+S%22">Hilal S</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lai+MKP%22">Lai MKP</searchLink>; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Choi+H%22">Choi H</searchLink>; Cardiovascular Metabolic Disease Translational Research Program, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Richards+AM%22">Richards AM</searchLink>; Cardiovascular Metabolic Disease Translational Research Program, National University of Singapore, Singapore, Singapore.; Christchurch Heart Institute, University of Otago, Dunedin North, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Centre for Innovation and Precision Eye Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+CLH%22">Chen CLH</searchLink>; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Mar; Vol. 21 (3), pp. e14601.
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              Text: 2025 Mar
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