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Chanoclavine synthase operates by an NADPH-independent superoxide mechanism.

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Title: Chanoclavine synthase operates by an NADPH-independent superoxide mechanism.
Authors: Chen CC; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Yu ZP; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, People's Republic of China., Liu Z; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Yao Y; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China., Hagedoorn PL; Biocatalysis, Department of Biotechnology, Delft University of Technology, Delft, The Netherlands., Schmitz RA; Biocatalysis, Department of Biotechnology, Delft University of Technology, Delft, The Netherlands., Yang L; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China., Yu L; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China., Liu A; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China.; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China., Sheng X; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China., Su H; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China., Ma Y; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China., Wang T; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Huang JW; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Zhang L; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Yan J; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China., Bao J; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China., Cui C; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China., Li X; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Shen P; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Zhang W; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, People's Republic of China., Min J; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China., Wang CY; MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, People's Republic of China., Guo RT; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China. guoreyting@hznu.edu.cn.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China. guoreyting@hznu.edu.cn., Gao SS; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China. gaoss@tib.cas.cn.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China. gaoss@tib.cas.cn.
Source: Nature [Nature] 2025 Apr; Vol. 640 (8059), pp. 840-846. Date of Electronic Publication: 2025 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Chanoclavine synthase operates by an NADPH-independent superoxide mechanism.
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  Data: <searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yu+ZP%22">Yu ZP</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yao+Y%22">Yao Y</searchLink>; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Hagedoorn+PL%22">Hagedoorn PL</searchLink>; Biocatalysis, Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schmitz+RA%22">Schmitz RA</searchLink>; Biocatalysis, Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+A%22">Liu A</searchLink>; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China.; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Sheng+X%22">Sheng X</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Su+H%22">Su H</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Huang+JW%22">Huang JW</searchLink>; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yan+J%22">Yan J</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Bao+J%22">Bao J</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Cui+C%22">Cui C</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Shen+P%22">Shen P</searchLink>; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China.; MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Min+J%22">Min J</searchLink>; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Guo+RT%22">Guo RT</searchLink>; Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, People's Republic of China. guoreyting@hznu.edu.cn.; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, People's Republic of China. guoreyting@hznu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Gao+SS%22">Gao SS</searchLink>; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China. gaoss@tib.cas.cn.; National Center of Technology Innovation for Synthetic Biology, Tianjin, People's Republic of China. gaoss@tib.cas.cn.
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