Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.
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| Title: | Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. |
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| Authors: | Roselli C; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Olesen MS; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Sveinbjornsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Marston NA; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Choi SH; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Chaffin M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gudbjartsson D; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Hill MC; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Aegisdottir H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Albert CM; Department of Cardiology, Cedars-Sinai, Los Angeles, CA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Anderson CD; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arking DE; McKusick Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Arnar DO; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Cardiovascular Centre, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Barnard J; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Benjamin EJ; Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Braunwald E; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Brumpton B; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Chami N; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Choi EK; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Christophersen IE; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Chung MK; Cardiovascular Medicine, Heart Vascular and Thoracic Institute and Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA., Conen D; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Crijns HJ; Department of Cardiology and CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA., Czuba T; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Lund University Diabetes Center, Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden., Damrauer SM; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany., Dudink E; Department of Cardiology and CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands., Duong T; McKusick Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Erikstrup C; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Fatkin D; Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; UNSW Sydney, Sydney, New South Wales, Australia.; St Vincent's Hospital, Sydney, New South Wales, Australia., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Ferreira M; Regeneron Genetics Center, Tarrytown, NY, USA., Freitag DF; Bayer Pharmaceuticals, Wuppertal, Germany., Ganesh SK; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA., Gaziano JM; Million Veteran Program, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Geelhoed B; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ghouse J; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kópavogur, Iceland., Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Haggerty C; Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Heckbert SR; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Ito K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Johnson R; Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; UNSW Sydney, Sydney, New South Wales, Australia., Jukema JW; Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Jurgens SJ; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Kääb S; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site: Munich Heart Alliance, Munich, Germany., Kane JP; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Kany S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Hamburg, Germany., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Khurshid S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Kamanu FK; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kirchhof P; Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Hamburg, Germany.; Institute of Cardiovascular Sciences, Birmingham, UK.; AFNET, Münster, Germany., Kleber ME; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Knight S; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Department of Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA., Komuro I; International University of Health and Welfare, Tokyo, Japan.; Department of Frontier Cardiovascular Science, The University of Tokyo, Tokyo, Japan., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Li D; Regeneron Genetics Center, Tarrytown, NY, USA., Lin H; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lin HJ; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lotta L; Regeneron Genetics Center, Tarrytown, NY, USA., Lubitz SA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Macfarlane PW; School of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK.; Electrocardiology Group, New Lister Building, Royal Infirmary, Glasgow, Scotland, UK., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Mantineo H; Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Marcus GM; Division of Cardiology, University of California, San Francisco, CA, USA., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany., McManus DD; University of Massachusetts Medical School, Worcester, MA, USA., Melander O; Department of Internal Medicine, Lund University and Skåne University Hospital, Malmö, Sweden., Melloni GEM; TIMI Study Group, Boston, MA, USA., Meyre PB; Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland., Miyazawa K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Mohanty S; Texas Cardiac Arrhythmia Institute, Austin, TX, USA., Monfort LM; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Müller-Nurasyid M; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany., Nafissi NA; Division of Cardiology, Duke University School of Medicine, Durham, NC, USA., Natale A; Texas Cardiac Arrhythmia Institute, Austin, TX, USA.; Department of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy., Nazarian S; Section of Cardiac Electrophysiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Pak HN; Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea., Pang S; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany., Pedersen OB; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil., Pirruccello JP; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Preuss M; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA, USA., Pullinger CR; Cardiovascular Research Institute and Department of Physiological Nursing, University of California, San Francisco, CA, USA., Rader DJ; Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Rämö JT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Risch L; Institute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland., Roden DM; Departments of Medicine Pharmacology and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Departments of Pediatrics and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Sabatine MS; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Schunkert H; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Partner site: Munich Heart Alliance, Munich, Germany., Shah SH; Division of Cardiology, Duke University School of Medicine, Durham, NC, USA., Shim J; Korea University Cardiovascular Center, Seoul, Republic of Korea., Shoemaker MB; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Simonson B; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sinner MF; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site: Munich Heart Alliance, Munich, Germany., Smit RAJ; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Smith NL; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA., Smith JG; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Lund University Diabetes Center, Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden., Soliman EZ; Epidemiological Cardiology Research Center, Section on Cardiovascular Medicine, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Sotoodehnia N; Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA., Strbian D; Department of Neurology and Neurosciences, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Stricker BH; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Teder-Laving M; Institute of Genomics, University of Tartu, Tartu, Estonia., Sun YV; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Thériault S; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, Québec, Canada., Thorolfsdottir RB; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tveit A; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., van der Harst P; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., van Meurs J; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Wang B; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Weiss S; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Wells QS; Departments of Medicine Pharmacology and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Weng LC; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; VA Boston Healthcare System, Boston, MA, USA., Wilson PW; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Atlanta VA Medical Center, Atlanta, GA, USA.; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Xiao L; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Yang PS; Cha University College of Medicine, Seoul, Republic of Korea., Yao J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Yoneda ZT; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Zeller T; German Center for Cardiovascular Research (DZHK), Hamburg, Germany.; University Center of Cardiovascular Sciences, Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zeng L; Bayer Pharmaceuticals, Wuppertal, Germany., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhou X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Zöllner S; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Ruff CT; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Bundgaard H; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Willer C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu.; Heart and Vascular Institute, Mass General Brigham, Boston, MA, USA. ellinor@mgh.harvard.edu. |
| Corporate Authors: | BioBank Japan Project, Regeneron Genetics Center, DBDS Genomic Consortium |
| Source: | Nature genetics [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 539-547. Date of Electronic Publication: 2025 Mar 06. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40050429 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Roselli+C%22">Roselli C</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Surakka+I%22">Surakka I</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Olesen+MS%22">Olesen MS</searchLink>; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sveinbjornsson+G%22">Sveinbjornsson G</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Marston+NA%22">Marston NA</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Choi+SH%22">Choi SH</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Holm+H%22">Holm H</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Chaffin+M%22">Chaffin M</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gudbjartsson+D%22">Gudbjartsson D</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Hill+MC%22">Hill MC</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aegisdottir+H%22">Aegisdottir H</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Albert+CM%22">Albert CM</searchLink>; Department of Cardiology, Cedars-Sinai, Los Angeles, CA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alonso+A%22">Alonso A</searchLink>; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+CD%22">Anderson CD</searchLink>; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Arking+DE%22">Arking DE</searchLink>; McKusick Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Arnar+DO%22">Arnar DO</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Cardiovascular Centre, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Barnard+J%22">Barnard J</searchLink>; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Benjamin+EJ%22">Benjamin EJ</searchLink>; Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Braunwald+E%22">Braunwald E</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brumpton+B%22">Brumpton B</searchLink>; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Campbell+A%22">Campbell A</searchLink>; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Chami+N%22">Chami N</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chasman+DI%22">Chasman DI</searchLink>; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+K%22">Cho K</searchLink>; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Choi+EK%22">Choi EK</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Christophersen+IE%22">Christophersen IE</searchLink>; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Chung+MK%22">Chung MK</searchLink>; Cardiovascular Medicine, Heart Vascular and Thoracic Institute and Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Conen+D%22">Conen D</searchLink>; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Crijns+HJ%22">Crijns HJ</searchLink>; Department of Cardiology and CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cutler+MJ%22">Cutler MJ</searchLink>; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.<br /><searchLink fieldCode="AU" term="%22Czuba+T%22">Czuba T</searchLink>; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Lund University Diabetes Center, Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Damrauer+SM%22">Damrauer SM</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dichgans+M%22">Dichgans M</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dörr+M%22">Dörr M</searchLink>; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Dudink+E%22">Dudink E</searchLink>; Department of Cardiology and CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Duong+T%22">Duong T</searchLink>; McKusick Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Erikstrup+C%22">Erikstrup C</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Esko+T%22">Esko T</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Fatkin+D%22">Fatkin D</searchLink>; Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; UNSW Sydney, Sydney, New South Wales, Australia.; St Vincent's Hospital, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Faul+JD%22">Faul JD</searchLink>; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+M%22">Ferreira M</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Freitag+DF%22">Freitag DF</searchLink>; Bayer Pharmaceuticals, Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Ganesh+SK%22">Ganesh SK</searchLink>; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gaziano+JM%22">Gaziano JM</searchLink>; Million Veteran Program, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Geelhoed+B%22">Geelhoed B</searchLink>; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ghouse+J%22">Ghouse J</searchLink>; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gieger+C%22">Gieger C</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Giulianini+F%22">Giulianini F</searchLink>; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Graham+SE%22">Graham SE</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gudnason+V%22">Gudnason V</searchLink>; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kópavogur, Iceland.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Haggerty+C%22">Haggerty C</searchLink>; Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hayward+C%22">Hayward C</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Heckbert+SR%22">Heckbert SR</searchLink>; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hveem+K%22">Hveem K</searchLink>; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Ito+K%22">Ito K</searchLink>; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Johnson+R%22">Johnson R</searchLink>; Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Jukema+JW%22">Jukema JW</searchLink>; Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jurgens+SJ%22">Jurgens SJ</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kääb+S%22">Kääb S</searchLink>; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site: Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kane+JP%22">Kane JP</searchLink>; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kany+S%22">Kany S</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kardia+SLR%22">Kardia SLR</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kavousi+M%22">Kavousi M</searchLink>; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Khurshid+S%22">Khurshid S</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kamanu+FK%22">Kamanu FK</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kirchhof+P%22">Kirchhof P</searchLink>; Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Hamburg, Germany.; Institute of Cardiovascular Sciences, Birmingham, UK.; AFNET, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Kleber+ME%22">Kleber ME</searchLink>; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Knight+S%22">Knight S</searchLink>; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Department of Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Komuro+I%22">Komuro I</searchLink>; International University of Health and Welfare, Tokyo, Japan.; Department of Frontier Cardiovascular Science, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Krieger+JE%22">Krieger JE</searchLink>; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Launer+LJ%22">Launer LJ</searchLink>; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+HJ%22">Lin HJ</searchLink>; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lotta+L%22">Lotta L</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lubitz+SA%22">Lubitz SA</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lunetta+KL%22">Lunetta KL</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Macfarlane+PW%22">Macfarlane PW</searchLink>; School of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK.; Electrocardiology Group, New Lister Building, Royal Infirmary, Glasgow, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Magnusson+PKE%22">Magnusson PKE</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Malik+R%22">Malik R</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mantineo+H%22">Mantineo H</searchLink>; Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Marcus+GM%22">Marcus GM</searchLink>; Division of Cardiology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22März+W%22">März W</searchLink>; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22McManus+DD%22">McManus DD</searchLink>; University of Massachusetts Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Melander+O%22">Melander O</searchLink>; Department of Internal Medicine, Lund University and Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Melloni+GEM%22">Melloni GEM</searchLink>; TIMI Study Group, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meyre+PB%22">Meyre PB</searchLink>; Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Miyazawa+K%22">Miyazawa K</searchLink>; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Mohanty+S%22">Mohanty S</searchLink>; Texas Cardiac Arrhythmia Institute, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Monfort+LM%22">Monfort LM</searchLink>; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Müller-Nurasyid+M%22">Müller-Nurasyid M</searchLink>; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Nafissi+NA%22">Nafissi NA</searchLink>; Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Natale+A%22">Natale A</searchLink>; Texas Cardiac Arrhythmia Institute, Austin, TX, USA.; Department of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nazarian+S%22">Nazarian S</searchLink>; Section of Cardiac Electrophysiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ostrowski+SR%22">Ostrowski SR</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pak+HN%22">Pak HN</searchLink>; Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Pang+S%22">Pang S</searchLink>; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pedersen+OB%22">Pedersen OB</searchLink>; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Pedersen+NL%22">Pedersen NL</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Pereira+AC%22">Pereira AC</searchLink>; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pirruccello+JP%22">Pirruccello JP</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Preuss+M%22">Preuss M</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Pullinger+CR%22">Pullinger CR</searchLink>; Cardiovascular Research Institute and Department of Physiological Nursing, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rader+DJ%22">Rader DJ</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rämö+JT%22">Rämö JT</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ridker+PM%22">Ridker PM</searchLink>; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rienstra+M%22">Rienstra M</searchLink>; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Risch+L%22">Risch L</searchLink>; Institute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Departments of Medicine Pharmacology and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Departments of Pediatrics and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sabatine+MS%22">Sabatine MS</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schunkert+H%22">Schunkert H</searchLink>; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Partner site: Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Shah+SH%22">Shah SH</searchLink>; Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Shim+J%22">Shim J</searchLink>; Korea University Cardiovascular Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shoemaker+MB%22">Shoemaker MB</searchLink>; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Simonson+B%22">Simonson B</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sinner+MF%22">Sinner MF</searchLink>; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site: Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Smit+RAJ%22">Smit RAJ</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Smith+NL%22">Smith NL</searchLink>; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JG%22">Smith JG</searchLink>; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Lund University Diabetes Center, Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Soliman+EZ%22">Soliman EZ</searchLink>; Epidemiological Cardiology Research Center, Section on Cardiovascular Medicine, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sørensen+E%22">Sørensen E</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sotoodehnia+N%22">Sotoodehnia N</searchLink>; Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Strbian+D%22">Strbian D</searchLink>; Department of Neurology and Neurosciences, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Stricker+BH%22">Stricker BH</searchLink>; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Teder-Laving+M%22">Teder-Laving M</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Sun+YV%22">Sun YV</searchLink>; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA.<br /><searchLink fieldCode="AU" term="%22Thériault+S%22">Thériault S</searchLink>; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Thorolfsdottir+RB%22">Thorolfsdottir RB</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Thorsteinsdottir+U%22">Thorsteinsdottir U</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Tveit+A%22">Tveit A</searchLink>; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22van+der+Harst+P%22">van der Harst P</searchLink>; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Meurs+J%22">van Meurs J</searchLink>; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+S%22">Weiss S</searchLink>; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Wells+QS%22">Wells QS</searchLink>; Departments of Medicine Pharmacology and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Weng+LC%22">Weng LC</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; VA Boston Healthcare System, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+PW%22">Wilson PW</searchLink>; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Atlanta VA Medical Center, Atlanta, GA, USA.; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+L%22">Xiao L</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+PS%22">Yang PS</searchLink>; Cha University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yoneda+ZT%22">Yoneda ZT</searchLink>; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Zeller+T%22">Zeller T</searchLink>; German Center for Cardiovascular Research (DZHK), Hamburg, Germany.; University Center of Cardiovascular Sciences, Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeng+L%22">Zeng L</searchLink>; Bayer Pharmaceuticals, Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zöllner+S%22">Zöllner S</searchLink>; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ruff+CT%22">Ruff CT</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bundgaard+H%22">Bundgaard H</searchLink>; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Willer+C%22">Willer C</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Ellinor+PT%22">Ellinor PT</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu.; Heart and Vascular Institute, Mass General Brigham, Boston, MA, USA. ellinor@mgh.harvard.edu. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22BioBank+Japan+Project%22">BioBank Japan Project</searchLink><br /><searchLink fieldCode="CA" term="%22Regeneron+Genetics+Center%22">Regeneron Genetics Center</searchLink><br /><searchLink fieldCode="CA" term="%22DBDS+Genomic+Consortium%22">DBDS Genomic Consortium</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 539-547. <i>Date of Electronic Publication: </i>2025 Mar 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Meta-Analysis – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE |
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