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Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.

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Title: Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.
Authors: Choi SH; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Jurgens SJ; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences (Heart Failure & Arrhythmias), Amsterdam UMC, Amsterdam, The Netherlands., Xiao L; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA., Hill MC; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA., Haggerty CM; Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA., Sveinbjörnsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Morrill VN; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Marston NA; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Weng LC; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA., Pirruccello JP; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.; Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA., Arnar DO; deCODE genetics/Amgen, Reykjavik, Iceland.; Cardiovascular Center, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Electical and Computer Engineering and School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Mantineo H; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., von Falkenhausen AS; Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Natale A; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA., Tveit A; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway., Geelhoed B; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Roselli C; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Van Wagoner DR; Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA., Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA., Haase D; Atrial Fibrillation NETwork (AFNET), Münster, Germany., Soliman EZ; Epidemiological Cardiology Research Center (EPICARE), Department of Internal Medicine, Cardiology Section, Wake Forest School of Medicine, Winston-Salem, NC, USA., Davogustto GE; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jun G; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Calkins H; Cardiac Arrhythmia Service, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Anderson JL; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Division of Cardiology, University of Utah, Salt Lake City, UT, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Halford JL; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA., Barnard J; Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA., Hokanson JE; Department of Epidemiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA., Smith JD; Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Young K; Department of Epidemiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA., Johnson LSB; Department of Clinical Physiology, Department of Clinical Sciences, Skåne University Hospital and Lund University, Lund, Sweden., Risch L; Institute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland., Gula LJ; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada., Kwee LC; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Chaffin MD; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kühne M; Cardiology/Electrophysiology, University Hospital Basel, University of Basel, Basel, Switzerland., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gupta N; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nafissi NA; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Nilsson PM; Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden.; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Wells QS; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Judy RL; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Schnabel RB; Atrial Fibrillation NETwork (AFNET), Münster, Germany.; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg/Kiel/Lübeck, Germany., Johnson R; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia., Smit RAJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gabriel S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Knight S; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Department of Medicine, University of Utah, Salt Lake City, UT, USA., Furukawa T; Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Nauffal V; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA., Wang X; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA., Min YI; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Yoneda ZT; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Laksman ZWM; Department of Medicine and the School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada., Bezzina CR; Department of Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences (Heart Failure & Arrhythmias), Amsterdam UMC, Amsterdam, The Netherlands., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Albert CM; Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Chasman DI; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Preventive Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rader DJ; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Conen D; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada., McManus DD; University of Massachusetts Chan Medical School Worcester, Worcester, MA, USA., Fatkin D; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; Cardiology Department, St. Vincent's Hospital, Sydney, New South Wales, Australia., Benjamin EJ; NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Marcus GM; Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA., Christophersen IE; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Smith JG; Department of Cardiology, Lund University Diabetes Center and Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden., Roberts JD; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada.; Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Shoemaker MB; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA., Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Chung MK; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA., S Olesen M; Laboratory for Molecular Cardiology, Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark., Sinner MF; Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Kirchhof P; Atrial Fibrillation NETwork (AFNET), Münster, Germany.; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg/Kiel/Lübeck, Germany.; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nazarian S; Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA., Mohanty S; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.; Dell Medical School, Austin, TX, USA., Damrauer SM; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Kaab S; Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Heckbert SR; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA., Redline S; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA., Shah SH; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Tanaka T; Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University (TMDU) Graduate School of Medical and Dental Sciences, Tokyo, Japan.; BioResource Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Ebana Y; Life Science and Bioethics Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Holm H; deCODE genetics/Amgen, Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ruff CT; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sabatine MS; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA., Lubitz SA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA. ellinor@mgh.harvard.edu.; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu.
Corporate Authors: Regeneron Genetics Center, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Source: Nature genetics [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 548-562. Date of Electronic Publication: 2025 Mar 06.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Choi+SH%22">Choi SH</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jurgens+SJ%22">Jurgens SJ</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences (Heart Failure & Arrhythmias), Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Xiao+L%22">Xiao L</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hill+MC%22">Hill MC</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haggerty+CM%22">Haggerty CM</searchLink>; Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sveinbjörnsson+G%22">Sveinbjörnsson G</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Morrill+VN%22">Morrill VN</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Marston+NA%22">Marston NA</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weng+LC%22">Weng LC</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pirruccello+JP%22">Pirruccello JP</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.; Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Arnar+DO%22">Arnar DO</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.; Cardiovascular Center, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gudbjartsson+DF%22">Gudbjartsson DF</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Electical and Computer Engineering and School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Mantineo+H%22">Mantineo H</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22von+Falkenhausen+AS%22">von Falkenhausen AS</searchLink>; Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Natale+A%22">Natale A</searchLink>; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tveit+A%22">Tveit A</searchLink>; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.<br /><searchLink fieldCode="AU" term="%22Geelhoed+B%22">Geelhoed B</searchLink>; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Roselli+C%22">Roselli C</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Van+Wagoner+DR%22">Van Wagoner DR</searchLink>; Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Darbar+D%22">Darbar D</searchLink>; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Haase+D%22">Haase D</searchLink>; Atrial Fibrillation NETwork (AFNET), Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Soliman+EZ%22">Soliman EZ</searchLink>; Epidemiological Cardiology Research Center (EPICARE), Department of Internal Medicine, Cardiology Section, Wake Forest School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Davogustto+GE%22">Davogustto GE</searchLink>; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jun+G%22">Jun G</searchLink>; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Calkins+H%22">Calkins H</searchLink>; Cardiac Arrhythmia Service, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+JL%22">Anderson JL</searchLink>; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Division of Cardiology, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Brody+JA%22">Brody JA</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Halford+JL%22">Halford JL</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Barnard+J%22">Barnard J</searchLink>; Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hokanson+JE%22">Hokanson JE</searchLink>; Department of Epidemiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JD%22">Smith JD</searchLink>; Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Young+K%22">Young K</searchLink>; Department of Epidemiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+LSB%22">Johnson LSB</searchLink>; Department of Clinical Physiology, Department of Clinical Sciences, Skåne University Hospital and Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Risch+L%22">Risch L</searchLink>; Institute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gula+LJ%22">Gula LJ</searchLink>; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kwee+LC%22">Kwee LC</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chaffin+MD%22">Chaffin MD</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kühne+M%22">Kühne M</searchLink>; Cardiology/Electrophysiology, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Preuss+M%22">Preuss M</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+N%22">Gupta N</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nafissi+NA%22">Nafissi NA</searchLink>; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Smith+NL%22">Smith NL</searchLink>; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Nilsson+PM%22">Nilsson PM</searchLink>; Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden.; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22van+der+Harst+P%22">van der Harst P</searchLink>; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wells+QS%22">Wells QS</searchLink>; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Judy+RL%22">Judy RL</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Schnabel+RB%22">Schnabel RB</searchLink>; Atrial Fibrillation NETwork (AFNET), Münster, Germany.; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg/Kiel/Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Johnson+R%22">Johnson R</searchLink>; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Smit+RAJ%22">Smit RAJ</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gabriel+S%22">Gabriel S</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Knight+S%22">Knight S</searchLink>; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Department of Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Furukawa+T%22">Furukawa T</searchLink>; Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Blackwell+TW%22">Blackwell TW</searchLink>; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Nauffal+V%22">Nauffal V</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Min+YI%22">Min YI</searchLink>; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.<br /><searchLink fieldCode="AU" term="%22Yoneda+ZT%22">Yoneda ZT</searchLink>; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Laksman+ZWM%22">Laksman ZWM</searchLink>; Department of Medicine and the School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Bezzina+CR%22">Bezzina CR</searchLink>; Department of Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences (Heart Failure & Arrhythmias), Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Alonso+A%22">Alonso A</searchLink>; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Albert+CM%22">Albert CM</searchLink>; Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Arking+DE%22">Arking DE</searchLink>; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chasman+DI%22">Chasman DI</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Preventive Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rader+DJ%22">Rader DJ</searchLink>; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Conen+D%22">Conen D</searchLink>; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22McManus+DD%22">McManus DD</searchLink>; University of Massachusetts Chan Medical School Worcester, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fatkin+D%22">Fatkin D</searchLink>; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; Cardiology Department, St. Vincent's Hospital, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Benjamin+EJ%22">Benjamin EJ</searchLink>; NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Marcus+GM%22">Marcus GM</searchLink>; Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Christophersen+IE%22">Christophersen IE</searchLink>; 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German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg/Kiel/Lübeck, Germany.; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nazarian+S%22">Nazarian S</searchLink>; Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mohanty+S%22">Mohanty S</searchLink>; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.; Dell Medical School, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Damrauer+SM%22">Damrauer SM</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kaab+S%22">Kaab S</searchLink>; Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heckbert+SR%22">Heckbert SR</searchLink>; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Redline+S%22">Redline S</searchLink>; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shah+SH%22">Shah SH</searchLink>; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Tanaka+T%22">Tanaka T</searchLink>; Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University (TMDU) Graduate School of Medical and Dental Sciences, Tokyo, Japan.; BioResource Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ebana+Y%22">Ebana Y</searchLink>; Life Science and Bioethics Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Holm+H%22">Holm H</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Ruff+CT%22">Ruff CT</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sabatine+MS%22">Sabatine MS</searchLink>; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lunetta+KL%22">Lunetta KL</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lubitz+SA%22">Lubitz SA</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA.; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ellinor+PT%22">Ellinor PT</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.; Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA. ellinor@mgh.harvard.edu.; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 548-562. <i>Date of Electronic Publication: </i>2025 Mar 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE
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      – TitleFull: Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.
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            NameFull: Heckbert SR
      – PersonEntity:
          Name:
            NameFull: Redline S
      – PersonEntity:
          Name:
            NameFull: Shah SH
      – PersonEntity:
          Name:
            NameFull: Tanaka T
      – PersonEntity:
          Name:
            NameFull: Ebana Y
      – PersonEntity:
          Name:
            NameFull: Holm H
      – PersonEntity:
          Name:
            NameFull: Stefansson K
      – PersonEntity:
          Name:
            NameFull: Ruff CT
      – PersonEntity:
          Name:
            NameFull: Sabatine MS
      – PersonEntity:
          Name:
            NameFull: Lunetta KL
      – PersonEntity:
          Name:
            NameFull: Lubitz SA
      – PersonEntity:
          Name:
            NameFull: Ellinor PT
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: 2025 Mar
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 57
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1