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Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions.

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Title: Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions.
Authors: Cheng WM; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Division of Urology, Department of Surgery, Zhongxiao Branch, Taipei City Hospital, Taipei, 115, Taiwan., Li PC; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Nguyen MT; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Lin YT; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Huang YT; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Cheng TS; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Department of Orthopedic Surgery, Far Eastern Memorial Hospital, New Taipei City, 220, Taiwan., Nguyen TH; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Institute of Biotechnology and Food Technology, Thai Nguyen University of Agriculture and Forestry, Thai Nguyen, Vietnam., Tran TH; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112, Taiwan., Huang TY; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Hoang TH; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Chen SY; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Chu YC; Taipei First Girls High School, Taipei, 110, Taiwan., Wu CW; Taipei First Girls High School, Taipei, 110, Taiwan., Lee MF; Department of Nutrition, China Medical University, Taichung, 406, Taiwan., Chiou YS; Master Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan., Liu HS; Medical Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; 13 M.Sc. Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; Center for Cancer Research, College of Medicine, Kaohsiung Medical University, Kaohsiung City, 807, Taiwan., Hong YR; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan., Chang PM; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Department of Oncology, Taipei Veterans General Hospital, Taipei, 112, Taiwan., Hu YF; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, 112, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, 115, Taipei, Taiwan., Chang YC; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.; Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA., Lai JM; Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City, 242, Taiwan. jmlai@mail.fju.edu.tw., Huang CF; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cyhuang5@nycu.edu.tw.; Chong Hin Loon Memorial Cancer and Biotherapy Research Center, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.
Source: Cancer cell international [Cancer Cell Int] 2025 Mar 06; Vol. 25 (1), pp. 79. Date of Electronic Publication: 2025 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139795 Publication Model: Electronic Cited Medium: Print ISSN: 1475-2867 (Print) Linking ISSN: 14752867 NLM ISO Abbreviation: Cancer Cell Int Subsets: PubMed not MEDLINE
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  Data: Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+WM%22">Cheng WM</searchLink>; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Division of Urology, Department of Surgery, Zhongxiao Branch, Taipei City Hospital, Taipei, 115, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+PC%22">Li PC</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+MT%22">Nguyen MT</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Lin+YT%22">Lin YT</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YT%22">Huang YT</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+TS%22">Cheng TS</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Department of Orthopedic Surgery, Far Eastern Memorial Hospital, New Taipei City, 220, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+TH%22">Nguyen TH</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Institute of Biotechnology and Food Technology, Thai Nguyen University of Agriculture and Forestry, Thai Nguyen, Vietnam.<br /><searchLink fieldCode="AU" term="%22Tran+TH%22">Tran TH</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+TY%22">Huang TY</searchLink>; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hoang+TH%22">Hoang TH</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SY%22">Chen SY</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+YC%22">Chu YC</searchLink>; Taipei First Girls High School, Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CW%22">Wu CW</searchLink>; Taipei First Girls High School, Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+MF%22">Lee MF</searchLink>; Department of Nutrition, China Medical University, Taichung, 406, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+YS%22">Chiou YS</searchLink>; Master Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+HS%22">Liu HS</searchLink>; Medical Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; 13 M.Sc. Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; Center for Cancer Research, College of Medicine, Kaohsiung Medical University, Kaohsiung City, 807, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+YR%22">Hong YR</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+PM%22">Chang PM</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Department of Oncology, Taipei Veterans General Hospital, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hu+YF%22">Hu YF</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.; Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, 112, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, 115, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+YC%22">Chang YC</searchLink>; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.; Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Lai+JM%22">Lai JM</searchLink>; Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City, 242, Taiwan. jmlai@mail.fju.edu.tw.<br /><searchLink fieldCode="AU" term="%22Huang+CF%22">Huang CF</searchLink>; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cyhuang5@nycu.edu.tw.; Chong Hin Loon Memorial Cancer and Biotherapy Research Center, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101139795%22">Cancer cell international</searchLink> [Cancer Cell Int] 2025 Mar 06; Vol. 25 (1), pp. 79. <i>Date of Electronic Publication: </i>2025 Mar 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101139795 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1475-2867 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752867%22">14752867 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Cell Int <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Mar 06
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