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Safety and efficacy of a fitusiran antithrombin-based dose regimen in people with hemophilia A or B: the ATLAS-OLE study.

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Title: Safety and efficacy of a fitusiran antithrombin-based dose regimen in people with hemophilia A or B: the ATLAS-OLE study.
Authors: Young G; Hemostasis and Thrombosis Center, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA., Kavakli K; Department of Pediatric Hematology and Oncology, Ege University Faculty of Medicine Children's Hospital, Izmir, Turkey., Klamroth R; Department for Internal Medicine and Vascular Medicine, Haemophilia Treatment Centre, Vivantes Hospital im Friedrichshain, Berlin, Germany., Matsushita T; Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan., Peyvandi F; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Pipe SW; Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI., Rangarajan S; Advanced Centre for Oncology, Haematology and Rare Diseases, K.J. Somaiya Super Specialty Hospital, Mumbai, India.; Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Shen MC; Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.; Department of Laboratory Medicine and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Srivastava A; Haematology Research Unit, St. Johns Research Institute and Department of Clinical Haematology, St. John's Medical College Hospital, Bengaluru, India., Sun J; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Tran H; Ronald Sawers Hemophilia Treatment Center, The Alfred Hospital, Monash University, Melbourne, VIC, Australia., You CW; Department of Pediatrics, Eulji University School of Medicine, Seoul, Republic of Korea., Zülfikar B; Division of Pediatric Hematology-Oncology, Istanbul University Oncology Institute, Istanbul, Turkey., Menapace LA; Sanofi, Cambridge, MA., Zhang C; Sanofi, Waltham, MA., Shen Y; Sanofi, Bridgewater, NJ., Puurunen M; Sanofi, Cambridge, MA., Demissie M; Sanofi, Cambridge, MA., Kenet G; National Hemophilia Centre, Amalia Biron Thrombosis Research Institute, Sheba Medical Centre, Ramat Gan, Israel.
Source: Blood [Blood] 2025 Jun 19; Vol. 145 (25), pp. 2966-2977.
Publication Type: Journal Article; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and efficacy of a fitusiran antithrombin-based dose regimen in people with hemophilia A or B: the ATLAS-OLE study.
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  Data: <searchLink fieldCode="AU" term="%22Young+G%22">Young G</searchLink>; Hemostasis and Thrombosis Center, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Kavakli+K%22">Kavakli K</searchLink>; Department of Pediatric Hematology and Oncology, Ege University Faculty of Medicine Children's Hospital, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Klamroth+R%22">Klamroth R</searchLink>; Department for Internal Medicine and Vascular Medicine, Haemophilia Treatment Centre, Vivantes Hospital im Friedrichshain, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Matsushita+T%22">Matsushita T</searchLink>; Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Peyvandi+F%22">Peyvandi F</searchLink>; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pipe+SW%22">Pipe SW</searchLink>; Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Rangarajan+S%22">Rangarajan S</searchLink>; Advanced Centre for Oncology, Haematology and Rare Diseases, K.J. Somaiya Super Specialty Hospital, Mumbai, India.; Faculty of Medicine, University of Southampton, Southampton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shen+MC%22">Shen MC</searchLink>; Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.; Department of Laboratory Medicine and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Srivastava+A%22">Srivastava A</searchLink>; Haematology Research Unit, St. Johns Research Institute and Department of Clinical Haematology, St. John's Medical College Hospital, Bengaluru, India.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tran+H%22">Tran H</searchLink>; Ronald Sawers Hemophilia Treatment Center, The Alfred Hospital, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22You+CW%22">You CW</searchLink>; Department of Pediatrics, Eulji University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zülfikar+B%22">Zülfikar B</searchLink>; Division of Pediatric Hematology-Oncology, Istanbul University Oncology Institute, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Menapace+LA%22">Menapace LA</searchLink>; Sanofi, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Sanofi, Waltham, MA.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; Sanofi, Bridgewater, NJ.<br /><searchLink fieldCode="AU" term="%22Puurunen+M%22">Puurunen M</searchLink>; Sanofi, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Demissie+M%22">Demissie M</searchLink>; Sanofi, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Kenet+G%22">Kenet G</searchLink>; National Hemophilia Centre, Amalia Biron Thrombosis Research Institute, Sheba Medical Centre, Ramat Gan, Israel.
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  Data: <searchLink fieldCode="JN" term="%227603509%22">Blood</searchLink> [Blood] 2025 Jun 19; Vol. 145 (25), pp. 2966-2977.
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  Data: Journal Article; Clinical Trial, Phase III; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603509 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0020 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200064971%22">00064971 </searchLink><i>NLM ISO Abbreviation: </i>Blood <i>Subsets: </i>MEDLINE
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