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Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications.

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Title: Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications.
Authors: Ahammed S; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Chowdhury R; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Al Hasan MS; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Mia E; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Akbor MS; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Islam MT; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Chowdhury RI; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Hossain MS; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh., Ansari IA; Department of Drug Science and Technology, University of Turin, 10124, Turin, Italy., Ansari SA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia., Islam MA; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh.; Department of Pharmacy, East West University, Dhaka, 1212, Bangladesh., Almarhoon ZM; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, 11451, Riyadh, Saudi Arabia., Sharifi-Rad J; Universidad Espíritu Santo, Samborondón, Ecuador. javad.sharifirad@gmail.com.; Centro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico. javad.sharifirad@gmail.com.; Department of Medicine, College of Medicine, Korea University, Seoul, 02841, Republic of Korea. javad.sharifirad@gmail.com., Setzer WN; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043, USA.; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Islam MT; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh. dmt.islam@bsmrstu.edu.bd.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh. dmt.islam@bsmrstu.edu.bd.; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh. dmt.islam@bsmrstu.edu.bd.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Aug; Vol. 398 (8), pp. 10921-10937. Date of Electronic Publication: 2025 Mar 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ahammed+S%22">Ahammed S</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Chowdhury+R%22">Chowdhury R</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Al+Hasan+MS%22">Al Hasan MS</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Mia+E%22">Mia E</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Akbor+MS%22">Akbor MS</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Islam+MT%22">Islam MT</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Chowdhury+RI%22">Chowdhury RI</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Hossain+MS%22">Hossain MS</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Ansari+IA%22">Ansari IA</searchLink>; Department of Drug Science and Technology, University of Turin, 10124, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Ansari+SA%22">Ansari SA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Islam+MA%22">Islam MA</searchLink>; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh.; Department of Pharmacy, East West University, Dhaka, 1212, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Almarhoon+ZM%22">Almarhoon ZM</searchLink>; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, 11451, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Sharifi-Rad+J%22">Sharifi-Rad J</searchLink>; Universidad Espíritu Santo, Samborondón, Ecuador. javad.sharifirad@gmail.com.; Centro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico. javad.sharifirad@gmail.com.; Department of Medicine, College of Medicine, Korea University, Seoul, 02841, Republic of Korea. javad.sharifirad@gmail.com.<br /><searchLink fieldCode="AU" term="%22Setzer+WN%22">Setzer WN</searchLink>; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043, USA.; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Islam+MT%22">Islam MT</searchLink>; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh. dmt.islam@bsmrstu.edu.bd.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh. dmt.islam@bsmrstu.edu.bd.; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh. dmt.islam@bsmrstu.edu.bd.
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