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Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial.

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Title: Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial.
Authors: Tie J; Division of Personalised Oncology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. jeanne.tie@petermac.org.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. jeanne.tie@petermac.org.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia. jeanne.tie@petermac.org., Wang Y; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lo SN; Research and Biostatistics, Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Lahouel K; Center for Cancer Prevention, Early Detection and Monitoring, City of Hope, Duarte, CA, USA.; Division of Integrated Cancer Genomics, Translational Genomics Research Institute, Phoenix, AZ, USA., Cohen JD; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wong R; Department of Medical Oncology, Eastern Health, Melbourne, Victoria, Australia.; Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Shapiro JD; Department of Medical Oncology, Cabrini Health, Melbourne, Victoria, Australia., Harris SJ; Department of Medical Oncology, Bendigo Health, Bendigo, Victoria, Australia., Khattak A; Department of Medical Oncology, Fiona Stanley Hospital, Perth, Western Australia, Australia.; Edith Cowan University, Perth, Western Australia, Australia., Burge ME; Department of Medical Oncology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Lee M; Department of Medical Oncology, Eastern Health, Melbourne, Victoria, Australia.; Department of Medical Oncology, Western Health, Melbourne, Victoria, Australia., Harris M; Department of Medical Oncology, Monash Health, Melbourne, Victoria, Australia., McLachlan SA; Department of Medical Oncology, St Vincent's Hospital, Melbourne, Victoria, Australia., Horvath L; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, New South Wales, Australia., Karapetis C; Department of Medical Oncology, Flinders Medical Centre, Adelaide, South Australia, Australia., Shannon J; Department of Medical Oncology, Nepean Cancer Care Centre, Kingswood, New South Wales, Australia., Singh M; Department of Medical Oncology, Barwon Health, Geelong, Victoria, Australia., Yip D; Department of Medical Oncology, Canberra Hospital, Canberra, Australian Capital Territory, Australia., Ananda S; Epworth Freemasons, Richmond, Melbourne, Victoria, Australia., Underhill C; Border Medical Oncology, Albury, New South Wales, Australia.; Rural Medical School, Albury Campus, University of NSW, Albury, New South Wales, Australia., Ptak J; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Silliman N; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Dobbyn L; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Popoli M; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Papadopoulos N; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tomasetti C; Center for Cancer Prevention, Early Detection and Monitoring, City of Hope, Duarte, CA, USA.; Division of Integrated Cancer Genomics, Translational Genomics Research Institute, Phoenix, AZ, USA., Kinzler KW; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Vogelstein B; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gibbs P; Division of Personalised Oncology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.; Department of Medical Oncology, Western Health, Melbourne, Victoria, Australia.
Source: Nature medicine [Nat Med] 2025 May; Vol. 31 (5), pp. 1509-1518. Date of Electronic Publication: 2025 Mar 07.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial.
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  Data: <searchLink fieldCode="AU" term="%22Tie+J%22">Tie J</searchLink>; Division of Personalised Oncology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. jeanne.tie@petermac.org.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. jeanne.tie@petermac.org.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia. jeanne.tie@petermac.org.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lo+SN%22">Lo SN</searchLink>; Research and Biostatistics, Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Lahouel+K%22">Lahouel K</searchLink>; Center for Cancer Prevention, Early Detection and Monitoring, City of Hope, Duarte, CA, USA.; Division of Integrated Cancer Genomics, Translational Genomics Research Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+JD%22">Cohen JD</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wong+R%22">Wong R</searchLink>; Department of Medical Oncology, Eastern Health, Melbourne, Victoria, Australia.; Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Shapiro+JD%22">Shapiro JD</searchLink>; Department of Medical Oncology, Cabrini Health, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Harris+SJ%22">Harris SJ</searchLink>; Department of Medical Oncology, Bendigo Health, Bendigo, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Khattak+A%22">Khattak A</searchLink>; 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Department of Medical Oncology, Flinders Medical Centre, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Shannon+J%22">Shannon J</searchLink>; Department of Medical Oncology, Nepean Cancer Care Centre, Kingswood, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Department of Medical Oncology, Barwon Health, Geelong, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yip+D%22">Yip D</searchLink>; Department of Medical Oncology, Canberra Hospital, Canberra, Australian Capital Territory, Australia.<br /><searchLink fieldCode="AU" term="%22Ananda+S%22">Ananda S</searchLink>; Epworth Freemasons, Richmond, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Underhill+C%22">Underhill C</searchLink>; Border Medical Oncology, Albury, New South Wales, Australia.; Rural Medical School, Albury Campus, University of NSW, Albury, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Ptak+J%22">Ptak J</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Silliman+N%22">Silliman N</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dobbyn+L%22">Dobbyn L</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Popoli+M%22">Popoli M</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Papadopoulos+N%22">Papadopoulos N</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tomasetti+C%22">Tomasetti C</searchLink>; Center for Cancer Prevention, Early Detection and Monitoring, City of Hope, Duarte, CA, USA.; Division of Integrated Cancer Genomics, Translational Genomics Research Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Kinzler+KW%22">Kinzler KW</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vogelstein+B%22">Vogelstein B</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gibbs+P%22">Gibbs P</searchLink>; Division of Personalised Oncology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.; Department of Medical Oncology, Western Health, Melbourne, Victoria, Australia.
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