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An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A.

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Title: An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A.
Authors: Rana J; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA., VanDyke D; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Muñoz-Melero M; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA., Fabilane CS; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland, USA., Thirumurugan S; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA., Arisa S; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA., Zhou B; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA., Spangler JB; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. Electronic address: jamie.spangler@jhu.edu., Biswas M; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA. Electronic address: nbiswas@iu.edu.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2025 Jun; Vol. 23 (6), pp. 1800-1809. Date of Electronic Publication: 2025 Mar 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A.
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  Data: <searchLink fieldCode="AU" term="%22Rana+J%22">Rana J</searchLink>; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22VanDyke+D%22">VanDyke D</searchLink>; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Muñoz-Melero+M%22">Muñoz-Melero M</searchLink>; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22Fabilane+CS%22">Fabilane CS</searchLink>; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Thirumurugan+S%22">Thirumurugan S</searchLink>; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22Arisa+S%22">Arisa S</searchLink>; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+B%22">Zhou B</searchLink>; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22Spangler+JB%22">Spangler JB</searchLink>; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. Electronic address: jamie.spangler@jhu.edu.<br /><searchLink fieldCode="AU" term="%22Biswas+M%22">Biswas M</searchLink>; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA. Electronic address: nbiswas@iu.edu.
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  Data: <searchLink fieldCode="JN" term="%22101170508%22">Journal of thrombosis and haemostasis : JTH</searchLink> [J Thromb Haemost] 2025 Jun; Vol. 23 (6), pp. 1800-1809. <i>Date of Electronic Publication: </i>2025 Mar 06.
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  Data: Journal Article; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170508 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7836 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215387836%22">15387836 </searchLink><i>NLM ISO Abbreviation: </i>J Thromb Haemost <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40056981
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      – Type: doi
        Value: 10.1016/j.jtha.2025.02.032
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      – Code: eng
        Text: English
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        StartPage: 1800
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      – TitleFull: An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A.
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            NameFull: Rana J
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            NameFull: VanDyke D
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            NameFull: Zhou B
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            – D: 01
              M: 06
              Text: 2025 Jun
              Type: published
              Y: 2025
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            – TitleFull: Journal of thrombosis and haemostasis : JTH
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