Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies.

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Title: Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies.
Authors: Doshi BS; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA., Markmann CA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Novak N; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Juarez Rojas S; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Davidson R; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Chau JQ; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Wang W; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA., Carrig S; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Martos Rus C; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Samelson-Jones BJ; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Small JC; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Bhoj VG; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vijay.bhoj@pennmedicine.upenn.edu., George LA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address: georgel@chop.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Jul 02; Vol. 33 (7), pp. 3073-3085. Date of Electronic Publication: 2025 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2025.03.003