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Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies.

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Title: Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies.
Authors: Doshi BS; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA., Markmann CA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Novak N; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Juarez Rojas S; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Davidson R; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Chau JQ; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Wang W; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA., Carrig S; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Martos Rus C; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Samelson-Jones BJ; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Small JC; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Bhoj VG; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vijay.bhoj@pennmedicine.upenn.edu., George LA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address: georgel@chop.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Jul 02; Vol. 33 (7), pp. 3073-3085. Date of Electronic Publication: 2025 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Doshi+BS%22">Doshi BS</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Markmann+CA%22">Markmann CA</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Novak+N%22">Novak N</searchLink>; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Juarez+Rojas+S%22">Juarez Rojas S</searchLink>; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+R%22">Davidson R</searchLink>; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Chau+JQ%22">Chau JQ</searchLink>; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Carrig+S%22">Carrig S</searchLink>; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Martos+Rus+C%22">Martos Rus C</searchLink>; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Samelson-Jones+BJ%22">Samelson-Jones BJ</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Small+JC%22">Small JC</searchLink>; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Bhoj+VG%22">Bhoj VG</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vijay.bhoj@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22George+LA%22">George LA</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address: georgel@chop.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ymthe.2025.03.003
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        Text: English
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