A Stratified Precision Medicine Trial Targeting Selective Mechanisms of Alpha 2A Agonism as a Treatment for the Cognitive Biotype of Depression: The BIomarker Guided (BIG) Study for Depression. - Williams L; Hack L; Jubeir J; Hilton R; Tozzi L; Boyar L; Zhang X; Lyons T; Jo B; O'Hara R; Schatzberg A (Research square, 2025)