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Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor.

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Title: Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor.
Authors: Poggialini F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Governa P; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Vagaggini C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Maramai S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Mugnaini C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Brizzi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Purgatorio R; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy., de Candia M; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy., Catto M; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy., Dreassi E; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Manetti F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Corelli F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Altomare CD; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy., Cappelli A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy., Paolino M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy. Electronic address: paolino3@unisi.it.
Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Jun 01; Vol. 209, pp. 107066. Date of Electronic Publication: 2025 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Poggialini+F%22">Poggialini F</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Governa+P%22">Governa P</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Vagaggini+C%22">Vagaggini C</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Maramai+S%22">Maramai S</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Lamponi+S%22">Lamponi S</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Mugnaini+C%22">Mugnaini C</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Brizzi+A%22">Brizzi A</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Purgatorio+R%22">Purgatorio R</searchLink>; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22de+Candia+M%22">de Candia M</searchLink>; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Catto+M%22">Catto M</searchLink>; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Dreassi+E%22">Dreassi E</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Manetti+F%22">Manetti F</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Corelli+F%22">Corelli F</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Altomare+CD%22">Altomare CD</searchLink>; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Cappelli+A%22">Cappelli A</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Paolino+M%22">Paolino M</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100, Siena, Italy. Electronic address: paolino3@unisi.it.
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