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Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes.

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Title: Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes.
Authors: Sørensen KV; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Justesen JM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ängquist L; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hartmann B; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen NR; Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Translational Research Centre, Rigshospitalet, Copenhagen, Denmark., Rungby J; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Herlev Hospital, Herlev, Denmark., Sørensen HT; Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.; Department of Epidemiology, Boston University, Boston, MA, USA., Vaag A; Steno Diabetes Center Copenhagen, Herlev Hospital, Herlev, Denmark.; Lund University Diabetes Care, Lund University, Malmö, Sweden.; Department of Endocrinology, Skåne University Hospital, Malmö, Sweden., Nielsen JS; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Holst JJ; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Herlev-Gentofte Hospital, Copenhagen, Denmark., Linneberg A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. niels.grarup@sund.ku.dk.
Source: Diabetologia [Diabetologia] 2025 May; Vol. 68 (5), pp. 1016-1030. Date of Electronic Publication: 2025 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA<subscript>1c</subscript> levels but not with type 2 diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Sørensen+KV%22">Sørensen KV</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Justesen+JM%22">Justesen JM</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ängquist+L%22">Ängquist L</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bork-Jensen+J%22">Bork-Jensen J</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hartmann+B%22">Hartmann B</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jørgensen+NR%22">Jørgensen NR</searchLink>; Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Translational Research Centre, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rungby+J%22">Rungby J</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Herlev Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+HT%22">Sørensen HT</searchLink>; Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.; Department of Epidemiology, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vaag+A%22">Vaag A</searchLink>; Steno Diabetes Center Copenhagen, Herlev Hospital, Herlev, Denmark.; Lund University Diabetes Care, Lund University, Malmö, Sweden.; Department of Endocrinology, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Nielsen+JS%22">Nielsen JS</searchLink>; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Holst+JJ%22">Holst JJ</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pedersen+O%22">Pedersen O</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Herlev-Gentofte Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Linneberg+A%22">Linneberg A</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hansen+T%22">Hansen T</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Grarup+N%22">Grarup N</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. niels.grarup@sund.ku.dk.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2025 May; Vol. 68 (5), pp. 1016-1030. <i>Date of Electronic Publication: </i>2025 Mar 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE
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