Liver fibrosis negatively impacts in vivo gene transfer to murine hepatocytes.

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Title: Liver fibrosis negatively impacts in vivo gene transfer to murine hepatocytes.
Authors: Simoni C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita Salute San Raffaele University, Milan, Italy., Nozi J; Généthon, Évry, France.; Université Paris-Saclay, Univ Évry, Inserm, Généthon, Integrare Research Unit UMR_S951, Évry, France., Starinieri F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., La Bella T; Généthon, Évry, France.; Université Paris-Saclay, Univ Évry, Inserm, Généthon, Integrare Research Unit UMR_S951, Évry, France., Manta E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Negri C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Biffi M; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Norata R; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Rocchi M; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sanvito F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ronzitti G; Généthon, Évry, France.; Université Paris-Saclay, Univ Évry, Inserm, Généthon, Integrare Research Unit UMR_S951, Évry, France., Barbon E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. barbon.elena@hsr.it., Cantore A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. cantore.alessio@hsr.it.; Vita Salute San Raffaele University, Milan, Italy. cantore.alessio@hsr.it.
Source: Nature communications [Nat Commun] 2025 Mar 10; Vol. 16 (1), pp. 2119. Date of Electronic Publication: 2025 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-57383-8