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Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.

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Title: Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.
Authors: Hurst JH; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Mohan AA; Department of Biomedical Engineering, Duke University School of Medicine, Durham, NC, USA., Dalapati T; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., George IA; Duke University School of Medicine, Durham, NC, USA., Aquino JN; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Lugo DJ; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Pfeiffer TS; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Rodriguez J; Children's Clinical Research Unit, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Rotta AT; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA., Turner NA; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Burke TW; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA., McClain MT; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA., Henao R; Department of Biostatistics and Informatics, Duke University, Durham, NC, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., DeMarco CT; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Louzao R; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Denny TN; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Walsh KM; Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA., Xu Z; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Mejias A; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Ramilo O; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Woods CW; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Kelly MS; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA. mkelly3@uams.edu.
Source: Nature communications [Nat Commun] 2025 Mar 10; Vol. 16 (1), pp. 2383. Date of Electronic Publication: 2025 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hurst+JH%22">Hurst JH</searchLink>; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mohan+AA%22">Mohan AA</searchLink>; Department of Biomedical Engineering, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Dalapati+T%22">Dalapati T</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22George+IA%22">George IA</searchLink>; Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Aquino+JN%22">Aquino JN</searchLink>; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lugo+DJ%22">Lugo DJ</searchLink>; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pfeiffer+TS%22">Pfeiffer TS</searchLink>; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+J%22">Rodriguez J</searchLink>; Children's Clinical Research Unit, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Rotta+AT%22">Rotta AT</searchLink>; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Turner+NA%22">Turner NA</searchLink>; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Burke+TW%22">Burke TW</searchLink>; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22McClain+MT%22">McClain MT</searchLink>; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Henao+R%22">Henao R</searchLink>; Department of Biostatistics and Informatics, Duke University, Durham, NC, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22DeMarco+CT%22">DeMarco CT</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Louzao+R%22">Louzao R</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Denny+TN%22">Denny TN</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+KM%22">Walsh KM</searchLink>; Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Mejias+A%22">Mejias A</searchLink>; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ramilo+O%22">Ramilo O</searchLink>; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Woods+CW%22">Woods CW</searchLink>; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+MS%22">Kelly MS</searchLink>; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA. mkelly3@uams.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Mar 10; Vol. 16 (1), pp. 2383. <i>Date of Electronic Publication: </i>2025 Mar 10.
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