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Pathogenic germline variants in cancer predisposition genes in patients with multiple primary cancers in an Asian population and the role of extended panel genetic testing.

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Title: Pathogenic germline variants in cancer predisposition genes in patients with multiple primary cancers in an Asian population and the role of extended panel genetic testing.
Authors: Cheo SW; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Zhao JJ; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Department of Medicine, National University Hospital, Singapore., Ong PY; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Ow SGW; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Ow CJL; Cancer Science Institute, National University of Singapore, Singapore., Chan GHJ; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Walsh RJ; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Lim JSJ; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute, National University of Singapore, Singapore., Lim SE; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Lim YW; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Wong ALA; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Wong JE; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Lee SC; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute, National University of Singapore, Singapore. Electronic address: csilsc@nus.edu.sg.
Source: ESMO open [ESMO Open] 2025 Mar; Vol. 10 (3), pp. 104495. Date of Electronic Publication: 2025 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pathogenic germline variants in cancer predisposition genes in patients with multiple primary cancers in an Asian population and the role of extended panel genetic testing.
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  Data: <searchLink fieldCode="AU" term="%22Cheo+SW%22">Cheo SW</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+JJ%22">Zhao JJ</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Department of Medicine, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+PY%22">Ong PY</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Ow+SGW%22">Ow SGW</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Ow+CJL%22">Ow CJL</searchLink>; Cancer Science Institute, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+GHJ%22">Chan GHJ</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Walsh+RJ%22">Walsh RJ</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+JSJ%22">Lim JSJ</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+SE%22">Lim SE</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+YW%22">Lim YW</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+ALA%22">Wong ALA</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+JE%22">Wong JE</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+SC%22">Lee SC</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute, National University of Singapore, Singapore. Electronic address: csilsc@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2025 Mar; Vol. 10 (3), pp. 104495. <i>Date of Electronic Publication: </i>2025 Mar 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101690685 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-7029 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220597029%22">20597029 </searchLink><i>NLM ISO Abbreviation: </i>ESMO Open <i>Subsets: </i>MEDLINE
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              Text: 2025 Mar
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