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IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma.

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Title: IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma.
Authors: Schmiechen ZC; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Nanda HA; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, Minnesota.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, Minnesota., Burrack AL; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Hickok GH; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Butler JZ; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Cruz-Hinojoza E; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Maurice NJ; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota., Geuenich MJ; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Yu C; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Tsai AK; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Lonetree CL; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Ellefson MA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Hilk AL; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Larsen BM; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Miller EA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Rizzo AB; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota., Campbell KR; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.; Department of Statistical Sciences, University of Toronto, Toronto, Canada.; Ontario Institute for Cancer Research, Toronto, Canada.; Vector Institute, Toronto, Canada., Shen SS; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, Minnesota.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, Minnesota., Stromnes IM; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota Medical School, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Source: Cancer immunology research [Cancer Immunol Res] 2025 Jun 04; Vol. 13 (6), pp. 847-866.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
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  Data: IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Schmiechen+ZC%22">Schmiechen ZC</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Nanda+HA%22">Nanda HA</searchLink>; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, Minnesota.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Burrack+AL%22">Burrack AL</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Hickok+GH%22">Hickok GH</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Butler+JZ%22">Butler JZ</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Cruz-Hinojoza+E%22">Cruz-Hinojoza E</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Maurice+NJ%22">Maurice NJ</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Geuenich+MJ%22">Geuenich MJ</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Tsai+AK%22">Tsai AK</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Lonetree+CL%22">Lonetree CL</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Ellefson+MA%22">Ellefson MA</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Hilk+AL%22">Hilk AL</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Larsen+BM%22">Larsen BM</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Miller+EA%22">Miller EA</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Rizzo+AB%22">Rizzo AB</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Campbell+KR%22">Campbell KR</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.; Department of Statistical Sciences, University of Toronto, Toronto, Canada.; Ontario Institute for Cancer Research, Toronto, Canada.; Vector Institute, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Shen+SS%22">Shen SS</searchLink>; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, Minnesota.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Stromnes+IM%22">Stromnes IM</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota Medical School, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101614637 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2326-6074 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223266066%22">23266066 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Res <i>Subsets: </i>MEDLINE
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