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Identification of effect modifiers using a stratified Mendelian randomization algorithmic framework.

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Title: Identification of effect modifiers using a stratified Mendelian randomization algorithmic framework.
Authors: Man A; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada., Knüsel L; Department of Computational Biology, University of Lausanne, CH-1015, Lausanne, Switzerland.; Center for Primary Care and Public Health, University of Lausanne, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., Graf J; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Computing and Software, Faculty of Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada., Lali R; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada., Le A; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada., Di Scipio M; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada., Mohammadi-Shemirani P; Takeda Development Center Americas, 500 Kendall Street, Cambridge, MA, 02142, USA., Chong M; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada., Pigeyre M; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada., Kutalik Z; Department of Computational Biology, University of Lausanne, CH-1015, Lausanne, Switzerland.; Center for Primary Care and Public Health, University of Lausanne, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., Paré G; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada. pareg@mcmaster.ca.; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. pareg@mcmaster.ca.; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. pareg@mcmaster.ca.; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada. pareg@mcmaster.ca.
Source: European journal of epidemiology [Eur J Epidemiol] 2025 Mar; Vol. 40 (3), pp. 275-296. Date of Electronic Publication: 2025 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 8508062 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7284 (Electronic) Linking ISSN: 03932990 NLM ISO Abbreviation: Eur J Epidemiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Man+A%22">Man A</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Knüsel+L%22">Knüsel L</searchLink>; Department of Computational Biology, University of Lausanne, CH-1015, Lausanne, Switzerland.; Center for Primary Care and Public Health, University of Lausanne, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Graf+J%22">Graf J</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Computing and Software, Faculty of Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Lali+R%22">Lali R</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Le+A%22">Le A</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Di+Scipio+M%22">Di Scipio M</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Mohammadi-Shemirani+P%22">Mohammadi-Shemirani P</searchLink>; Takeda Development Center Americas, 500 Kendall Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Chong+M%22">Chong M</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.<br /><searchLink fieldCode="AU" term="%22Pigeyre+M%22">Pigeyre M</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.; Department of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Kutalik+Z%22">Kutalik Z</searchLink>; Department of Computational Biology, University of Lausanne, CH-1015, Lausanne, Switzerland.; Center for Primary Care and Public Health, University of Lausanne, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Paré+G%22">Paré G</searchLink>; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada. pareg@mcmaster.ca.; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. pareg@mcmaster.ca.; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. pareg@mcmaster.ca.; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada. pareg@mcmaster.ca.
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