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SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy.

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Title: SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy.
Authors: Millan AJ; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States., Allain V; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, United States.; INSERM UMR976, Hôpital Saint-Louis, Université Paris Cité, Paris, France., Nayak I; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, College of Medicine, The Ohio State University, Columbus, OH, United States., Libang JB; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States., Quijada-Madrid LM; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States., Arakawa-Hoyt JS; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States., Ureno G; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States., Rothrock AG; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, United States., Shemesh A; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States., Aguilar OA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States., Eyquem J; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.; INSERM UMR976, Hôpital Saint-Louis, Université Paris Cité, Paris, France., Das J; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, College of Medicine, The Ohio State University, Columbus, OH, United States.; Department of Pediatrics, Nationwide Children's Hospital, College of Medicine, The Ohio State University, Columbus, OH, United States.; Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH, United States.; Pelotonia Institute for Immuno-Oncology, College of Medicine, The Ohio State University, Columbus, OH, United States., Lanier LL; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.
Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Mar 01; Vol. 214 (3), pp. 384-398.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Millan+AJ%22">Millan AJ</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Allain+V%22">Allain V</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, United States.; INSERM UMR976, Hôpital Saint-Louis, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Nayak+I%22">Nayak I</searchLink>; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, College of Medicine, The Ohio State University, Columbus, OH, United States.<br /><searchLink fieldCode="AU" term="%22Libang+JB%22">Libang JB</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Quijada-Madrid+LM%22">Quijada-Madrid LM</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Arakawa-Hoyt+JS%22">Arakawa-Hoyt JS</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Ureno+G%22">Ureno G</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Rothrock+AG%22">Rothrock AG</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Shemesh+A%22">Shemesh A</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Aguilar+OA%22">Aguilar OA</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.<br /><searchLink fieldCode="AU" term="%22Eyquem+J%22">Eyquem J</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.; INSERM UMR976, Hôpital Saint-Louis, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Das+J%22">Das J</searchLink>; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, College of Medicine, The Ohio State University, Columbus, OH, United States.; Department of Pediatrics, Nationwide Children's Hospital, College of Medicine, The Ohio State University, Columbus, OH, United States.; Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH, United States.; Pelotonia Institute for Immuno-Oncology, College of Medicine, The Ohio State University, Columbus, OH, United States.<br /><searchLink fieldCode="AU" term="%22Lanier+LL%22">Lanier LL</searchLink>; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.
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  Data: <searchLink fieldCode="JN" term="%222985117R%22">Journal of immunology (Baltimore, Md. : 1950)</searchLink> [J Immunol] 2025 Mar 01; Vol. 214 (3), pp. 384-398.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985117R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-6606 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221767%22">00221767 </searchLink><i>NLM ISO Abbreviation: </i>J Immunol <i>Subsets: </i>MEDLINE
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