Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.

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Title: Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.
Authors: Sugimoto A; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Saito Y; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA.; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan., Wang G; Division of Vascular Oncology and Metastasis Research, German Cancer Research Center, Heidelberg, Germany.; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Sun Q; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Yin C; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Lee KH; Division of Vascular Oncology and Metastasis Research, German Cancer Research Center, Heidelberg, Germany.; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Geng Y; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Rajbhandari P; Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA., Hernandez C; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Steffani M; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Qie J; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Savage T; Department of Microbiology & Immunology, Columbia University, New York, NY, USA., Goyal DM; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Ray KC; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Neelakantan TV; Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA., Yin D; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Melms J; Department of Medicine, Columbia University, New York, NY, USA., Lehrich BM; Department of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yasaka TM; Department of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Liu S; Department of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Oertel M; Department of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lan T; Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Guillot A; Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Peiseler M; Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Filliol A; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Kanzaki H; Liver Tumour Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA., Fujiwara N; Liver Tumour Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ravi S; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Izar B; Department of Medicine, Columbia University, New York, NY, USA.; Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, New York, NY, USA., Brosch M; Department of Internal Medicine I, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Hampe J; Department of Internal Medicine I, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Remotti H; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Argemi J; Liver Unit and RNA Biology and Therapies Program, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain., Sun Z; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kendall TJ; Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Hoshida Y; Liver Tumour Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA., Tacke F; Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Fallowfield JA; Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Blockley-Powell SK; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Haeusler RA; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA., Steinman JB; Department of Pediatrics, Columbia University, New York, NY, USA., Pajvani UB; Department of Medicine, Columbia University, New York, NY, USA.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA.; Institute of Human Nutrition, New York, NY, USA., Monga SP; Department of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bataller R; Liver Unit,Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain., Masoodi M; Institute of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland., Arpaia N; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA.; Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, New York, NY, USA., Lee YA; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Stockwell BR; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA.; Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, New York, NY, USA., Augustin HG; Division of Vascular Oncology and Metastasis Research, German Cancer Research Center, Heidelberg, Germany. augustin@angioscience.de.; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. augustin@angioscience.de., Schwabe RF; Department of Medicine, Columbia University, New York, NY, USA. rfs2102@cumc.columbia.edu.; Columbia University Digestive and Liver Disease Research Center, New York, NY, USA. rfs2102@cumc.columbia.edu.; Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany. rfs2102@cumc.columbia.edu.; Institute of Human Nutrition, New York, NY, USA. rfs2102@cumc.columbia.edu.; Burch-Lodge Center for Human Longevity, Columbia University, New York, NY, USA. rfs2102@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, New York, NY, USA. rfs2102@cumc.columbia.edu.
Source: Nature [Nature] 2025 Apr; Vol. 640 (8059), pp. 752-761. Date of Electronic Publication: 2025 Mar 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-08677-w