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Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as dual CDK2/PIM1 inhibitors with potent anti-cancer activity and selectivity.

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Title: Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as dual CDK2/PIM1 inhibitors with potent anti-cancer activity and selectivity.
Authors: Elkotamy MS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt., Elgohary MK; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt., Alkabbani MA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt., Binjubair FA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Alsulaimany M; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medina, Saudi Arabia., Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Ghabbour HA; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia., Abdel-Aziz HA; Applied Organic Chemistry Department, National Research Center, Dokki, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2026 Feb; Vol. 44 (2), pp. 1064-1088. Date of Electronic Publication: 2025 Mar 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as dual CDK2/PIM1 inhibitors with potent anti-cancer activity and selectivity.
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  Data: <searchLink fieldCode="AU" term="%22Elkotamy+MS%22">Elkotamy MS</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt.<br /><searchLink fieldCode="AU" term="%22Elgohary+MK%22">Elgohary MK</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt.<br /><searchLink fieldCode="AU" term="%22Alkabbani+MA%22">Alkabbani MA</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt.<br /><searchLink fieldCode="AU" term="%22Binjubair+FA%22">Binjubair FA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alanazi+MM%22">Alanazi MM</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alsulaimany+M%22">Alsulaimany M</searchLink>; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medina, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Rashood+ST%22">Al-Rashood ST</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ghabbour+HA%22">Ghabbour HA</searchLink>; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Abdel-Aziz+HA%22">Abdel-Aziz HA</searchLink>; Applied Organic Chemistry Department, National Research Center, Dokki, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
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  Data: <searchLink fieldCode="JN" term="%228404176%22">Journal of biomolecular structure & dynamics</searchLink> [J Biomol Struct Dyn] 2026 Feb; Vol. 44 (2), pp. 1064-1088. <i>Date of Electronic Publication: </i>2025 Mar 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8404176 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-0254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207391102%22">07391102 </searchLink><i>NLM ISO Abbreviation: </i>J Biomol Struct Dyn <i>Subsets: </i>MEDLINE
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        Value: 10.1080/07391102.2025.2475233
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        Text: English
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              Text: 2026 Feb
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