Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials.

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Title: Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials.
Authors: Dinges SM; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany., Schwedhelm E; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Str. 58, 10785 Berlin, Germany., Schoenfeld J; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany., Gevaert AB; Department of Cardiology, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium.; Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium., Winzer EB; Department of Internal Medicine/Cardiology, University Clinic, Heart Center, Technische Universität Dresden, Fetscherstr. 76, 01307 Dresden, Germany., Haller B; Technical University of Munich, TUM School of Medicine and Health, Institute for AI and Informatics in Medicine, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany., Baldassarri F; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany., Pressler A; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; Private Center for Sports and Preventive Cardiology, Törringstraße 6, 81675 Munich, Germany., Duvinage A; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany., Böger R; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Str. 58, 10785 Berlin, Germany., Linke A; Department of Internal Medicine/Cardiology, University Clinic, Heart Center, Technische Universität Dresden, Fetscherstr. 76, 01307 Dresden, Germany., Adams V; Department of Internal Medicine/Cardiology, University Clinic, Heart Center, Technische Universität Dresden, Fetscherstr. 76, 01307 Dresden, Germany., Pieske B; Division of Cardiology, Department of Internal Medicine, University Medicine Rostock, Schillingallee 35, 18057 Rostock, Germany., Edelmann F; Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Deutsches Herzzentrum der Charité, Augustenburger Platz 1, 13353 Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany., Dalen H; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Clinic of Cardiology, St. Olavs University Hospital, Postbox 3250 Torgarden, 7006 Trondheim, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Postbox 333, 7601 Levanger, Norway., Hole T; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Department of Medicine, Ålesund Hospital, Møre og Romsdal Hospital Trust, Postbox 1600, 6026 Ålesund, Norway., Larsen AI; Department of Cardiology, Stavanger University Hospital, Gerd Ragna Bloch Thorsens gate 8, 4011 Stavanger, Norway.; Institute of Clinical Science, University of Bergen, Jonas Lies vei 87, 5021 Bergen, Norway., Feiereisen P; Department of Cardiology, Centre Hospitalier de Luxembourg, 4 Rue Nicolas Ernest Barblé, 1210 Luxembourg, Luxembourg., Karlsen T; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Faculty of Nursing and Health Sciences, Nord University, Universitetsalléen 1, 8026 Bodø, Norway., Prescott E; Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen 2400, Denmark., Ellingsen Ø; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Clinic of Cardiology, St. Olavs University Hospital, Postbox 3250 Torgarden, 7006 Trondheim, Norway., Van Craenenbroeck EM; Department of Cardiology, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium.; Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium., Halle M; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany., Mueller S; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany.
Source: European journal of preventive cardiology [Eur J Prev Cardiol] 2025 Aug 25; Vol. 32 (11), pp. 949-960.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101564430 Publication Model: Print Cited Medium: Internet ISSN: 2047-4881 (Electronic) Linking ISSN: 20474873 NLM ISO Abbreviation: Eur J Prev Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials.
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  Data: <searchLink fieldCode="AU" term="%22Dinges+SM%22">Dinges SM</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schwedhelm+E%22">Schwedhelm E</searchLink>; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schoenfeld+J%22">Schoenfeld J</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gevaert+AB%22">Gevaert AB</searchLink>; Department of Cardiology, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium.; Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Winzer+EB%22">Winzer EB</searchLink>; Department of Internal Medicine/Cardiology, University Clinic, Heart Center, Technische Universität Dresden, Fetscherstr. 76, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Haller+B%22">Haller B</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Institute for AI and Informatics in Medicine, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Baldassarri+F%22">Baldassarri F</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pressler+A%22">Pressler A</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; Private Center for Sports and Preventive Cardiology, Törringstraße 6, 81675 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Duvinage+A%22">Duvinage A</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Böger+R%22">Böger R</searchLink>; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Linke+A%22">Linke A</searchLink>; Department of Internal Medicine/Cardiology, University Clinic, Heart Center, Technische Universität Dresden, Fetscherstr. 76, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Adams+V%22">Adams V</searchLink>; Department of Internal Medicine/Cardiology, University Clinic, Heart Center, Technische Universität Dresden, Fetscherstr. 76, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Pieske+B%22">Pieske B</searchLink>; Division of Cardiology, Department of Internal Medicine, University Medicine Rostock, Schillingallee 35, 18057 Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Edelmann+F%22">Edelmann F</searchLink>; Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Deutsches Herzzentrum der Charité, Augustenburger Platz 1, 13353 Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dalen+H%22">Dalen H</searchLink>; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Clinic of Cardiology, St. Olavs University Hospital, Postbox 3250 Torgarden, 7006 Trondheim, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Postbox 333, 7601 Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Hole+T%22">Hole T</searchLink>; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Department of Medicine, Ålesund Hospital, Møre og Romsdal Hospital Trust, Postbox 1600, 6026 Ålesund, Norway.<br /><searchLink fieldCode="AU" term="%22Larsen+AI%22">Larsen AI</searchLink>; Department of Cardiology, Stavanger University Hospital, Gerd Ragna Bloch Thorsens gate 8, 4011 Stavanger, Norway.; Institute of Clinical Science, University of Bergen, Jonas Lies vei 87, 5021 Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Feiereisen+P%22">Feiereisen P</searchLink>; Department of Cardiology, Centre Hospitalier de Luxembourg, 4 Rue Nicolas Ernest Barblé, 1210 Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Karlsen+T%22">Karlsen T</searchLink>; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Faculty of Nursing and Health Sciences, Nord University, Universitetsalléen 1, 8026 Bodø, Norway.<br /><searchLink fieldCode="AU" term="%22Prescott+E%22">Prescott E</searchLink>; Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen 2400, Denmark.<br /><searchLink fieldCode="AU" term="%22Ellingsen+Ø%22">Ellingsen Ø</searchLink>; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.; Clinic of Cardiology, St. Olavs University Hospital, Postbox 3250 Torgarden, 7006 Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Van+Craenenbroeck+EM%22">Van Craenenbroeck EM</searchLink>; Department of Cardiology, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium.; Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Halle+M%22">Halle M</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Technical University of Munich, TUM School of Medicine and Health, Department for Preventive Sports Medicine and Sports Cardiology, TUM University Hospital, Georg-Brauchle-Ring 56, 80992 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Potsdamer Str. 58, 10785 Berlin, Germany.
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