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Effective targeting of PDGFRA-altered high-grade glioma with avapritinib.

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Title: Effective targeting of PDGFRA-altered high-grade glioma with avapritinib.
Authors: Mayr L; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Neyazi S; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Schwark K; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Trissal M; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Beck A; Center for Neuropathology and Prion Research, Ludwig Maximilians University Munich, Faculty of Medicine, Muenchen, 80539 Bayern, Germany., Labelle J; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Eder SK; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna and St. Anna Children's Cancer Research Institute (CCRI), 1090 Vienna, Austria., Weiler-Wichtl L; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Marques JG; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., de Biagi-Junior CAO; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Lo Cascio C; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Chapman O; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA., Sridhar S; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA., Kenkre R; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA., Dutta A; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA., Wang S; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA., Wang J; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA., Hack O; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Nascimento A; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Nguyen CM; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Castellani S; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Rozowsky JS; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Groves A; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Panditharatna E; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Cruzeiro GAV; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Haase RD; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Tabatabai K; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Madlener S; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Wadden J; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Adam T; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Kong S; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Miclea M; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Patel T; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Bruckner K; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Department of Neurosurgery, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Senfter D; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Lämmerer A; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Research Cluster 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, 1090 Vienna, Austria., Supko J; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Guntner AS; Institute for Analytical and General Chemistry, Johannes Kepler University, 4040 Linz, Austria., Palova H; Central European Institute of Technology, Masaryk University, 60177 Brno, Czech Republic., Neradil J; Department of Experimental Biology, Faculty of Science, Masaryk University, 61137 Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic., Stepien N; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Lötsch-Gojo D; Department of Neurosurgery, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Berger W; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Research Cluster 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, 1090 Vienna, Austria., Leiss U; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Rosenmayr V; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Dorfer C; Department of Neurosurgery, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Dieckmann K; Department of Radiotherapy, Medical University of Vienna, 1090 Vienna, Austria., Peyrl A; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Azizi AA; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Baumgartner A; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Slaby O; Central European Institute of Technology, Masaryk University, 60177 Brno, Czech Republic; Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic., Pokorna P; Central European Institute of Technology, Masaryk University, 60177 Brno, Czech Republic., Clark LM; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA., Cameron A; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Dubois F; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Greenwald NF; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02115, USA., Bandopadhayay P; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Beroukhim R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA., Ligon K; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA., Kramm C; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, 37099 Göttingen, Germany., Bronsema A; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Bailey S; Great North Childrens Hospital and Newcastle University, Newcastle upon Tyne, UK; Newcastle Hospitals NHS Foundation Trust, NE1 4LP Newcastle, UK., Stucklin AG; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, 8008 Zurich, Switzerland., Mueller S; Departments of Pediatrics, Neurology, and Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Skrypek M; Department of Pediatric Hematology-Oncology, Children's Minnesota, Minneapolis, MN 55404, USA., Martinez N; Department of Neurology & Neurological Surgery, Jefferson University, Philadelphia, PA 19107, USA., Bowers DC; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Jones C; Division of Molecular Pathology, Institute of Cancer Research, SM2 5NG London, UK., Jäger N; Hopp Children's Cancer Center Heidelberg (KiTZ) & Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Sterba J; Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, 662630 Brno, Czech Republic., Müllauer L; Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria., Haberler C; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria., Kumar-Sinha C; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Chinnaiyan A; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mody R; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Chavez L; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA., Furtner J; Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria; Research Center of Medical Image Analysis and Artificial Intelligence, Danube Private University, 3500 Krems an der Donau, Austria., Koschmann C; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: ckoschma@med.umich.edu., Gojo J; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria. Electronic address: johannes.gojo@meduniwien.ac.at., Filbin MG; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: mariella.filbin@childrens.harvard.edu.
Source: Cancer cell [Cancer Cell] 2025 Apr 14; Vol. 43 (4), pp. 740-756.e8. Date of Electronic Publication: 2025 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
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  Data: Effective targeting of PDGFRA-altered high-grade glioma with avapritinib.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Mayr+L%22">Mayr L</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Neyazi+S%22">Neyazi S</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Schwark+K%22">Schwark K</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Trissal+M%22">Trissal M</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Beck+A%22">Beck A</searchLink>; Center for Neuropathology and Prion Research, Ludwig Maximilians University Munich, Faculty of Medicine, Muenchen, 80539 Bayern, Germany.<br /><searchLink fieldCode="AU" term="%22Labelle+J%22">Labelle J</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Eder+SK%22">Eder SK</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna and St. Anna Children's Cancer Research Institute (CCRI), 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Weiler-Wichtl+L%22">Weiler-Wichtl L</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Marques+JG%22">Marques JG</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22de+Biagi-Junior+CAO%22">de Biagi-Junior CAO</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Lo+Cascio+C%22">Lo Cascio C</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Chapman+O%22">Chapman O</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Sridhar+S%22">Sridhar S</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Kenkre+R%22">Kenkre R</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+A%22">Dutta A</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Hack+O%22">Hack O</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Nascimento+A%22">Nascimento A</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+CM%22">Nguyen CM</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Castellani+S%22">Castellani S</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Rozowsky+JS%22">Rozowsky JS</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Groves+A%22">Groves A</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Panditharatna+E%22">Panditharatna E</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Cruzeiro+GAV%22">Cruzeiro GAV</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Haase+RD%22">Haase RD</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Tabatabai+K%22">Tabatabai K</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Madlener+S%22">Madlener S</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wadden+J%22">Wadden J</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Adam+T%22">Adam T</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Kong+S%22">Kong S</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Miclea+M%22">Miclea M</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Patel+T%22">Patel T</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Bruckner+K%22">Bruckner K</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Department of Neurosurgery, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Senfter+D%22">Senfter D</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lämmerer+A%22">Lämmerer A</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Research Cluster 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Supko+J%22">Supko J</searchLink>; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Guntner+AS%22">Guntner AS</searchLink>; Institute for Analytical and General Chemistry, Johannes Kepler University, 4040 Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Palova+H%22">Palova H</searchLink>; Central European Institute of Technology, Masaryk University, 60177 Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Neradil+J%22">Neradil J</searchLink>; Department of Experimental Biology, Faculty of Science, Masaryk University, 61137 Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Stepien+N%22">Stepien N</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lötsch-Gojo+D%22">Lötsch-Gojo D</searchLink>; Department of Neurosurgery, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Berger+W%22">Berger W</searchLink>; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Research Cluster 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Leiss+U%22">Leiss U</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Rosenmayr+V%22">Rosenmayr V</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dorfer+C%22">Dorfer C</searchLink>; Department of Neurosurgery, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dieckmann+K%22">Dieckmann K</searchLink>; Department of Radiotherapy, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Peyrl+A%22">Peyrl A</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Azizi+AA%22">Azizi AA</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Baumgartner+A%22">Baumgartner A</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Slaby+O%22">Slaby O</searchLink>; Central European Institute of Technology, Masaryk University, 60177 Brno, Czech Republic; Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Pokorna+P%22">Pokorna P</searchLink>; Central European Institute of Technology, Masaryk University, 60177 Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Clark+LM%22">Clark LM</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA.<br /><searchLink fieldCode="AU" term="%22Cameron+A%22">Cameron A</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+QD%22">Nguyen QD</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA.<br /><searchLink fieldCode="AU" term="%22Wakimoto+H%22">Wakimoto H</searchLink>; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Dubois+F%22">Dubois F</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Greenwald+NF%22">Greenwald NF</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Bandopadhayay+P%22">Bandopadhayay P</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Beroukhim+R%22">Beroukhim R</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Ligon+K%22">Ligon K</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Kramm+C%22">Kramm C</searchLink>; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, 37099 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bronsema+A%22">Bronsema A</searchLink>; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bailey+S%22">Bailey S</searchLink>; Great North Childrens Hospital and Newcastle University, Newcastle upon Tyne, UK; Newcastle Hospitals NHS Foundation Trust, NE1 4LP Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Stucklin+AG%22">Stucklin AG</searchLink>; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, 8008 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Departments of Pediatrics, Neurology, and Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Skrypek+M%22">Skrypek M</searchLink>; Department of Pediatric Hematology-Oncology, Children's Minnesota, Minneapolis, MN 55404, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+N%22">Martinez N</searchLink>; Department of Neurology & Neurological Surgery, Jefferson University, Philadelphia, PA 19107, USA.<br /><searchLink fieldCode="AU" term="%22Bowers+DC%22">Bowers DC</searchLink>; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+C%22">Jones C</searchLink>; Division of Molecular Pathology, Institute of Cancer Research, SM2 5NG London, UK.<br /><searchLink fieldCode="AU" term="%22Jäger+N%22">Jäger N</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ) & Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sterba+J%22">Sterba J</searchLink>; Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, 662630 Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Müllauer+L%22">Müllauer L</searchLink>; Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Haberler+C%22">Haberler C</searchLink>; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kumar-Sinha+C%22">Kumar-Sinha C</searchLink>; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Chinnaiyan+A%22">Chinnaiyan A</searchLink>; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Mody+R%22">Mody R</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Chavez+L%22">Chavez L</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Furtner+J%22">Furtner J</searchLink>; Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria; Research Center of Medical Image Analysis and Artificial Intelligence, Danube Private University, 3500 Krems an der Donau, Austria.<br /><searchLink fieldCode="AU" term="%22Koschmann+C%22">Koschmann C</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: ckoschma@med.umich.edu.<br /><searchLink fieldCode="AU" term="%22Gojo+J%22">Gojo J</searchLink>; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria. Electronic address: johannes.gojo@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Filbin+MG%22">Filbin MG</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: mariella.filbin@childrens.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101130617%22">Cancer cell</searchLink> [Cancer Cell] 2025 Apr 14; Vol. 43 (4), pp. 740-756.e8. <i>Date of Electronic Publication: </i>2025 Mar 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130617 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-3686 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215356108%22">15356108 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Cell <i>Subsets: </i>MEDLINE
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              Text: 2025 Apr 14
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