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The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT2C Receptors.

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Title: The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT2C Receptors.
Authors: Zhang X; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China., He XL; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Jiang ZH; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Qi J; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Huang CC; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Zhao JS; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Gu N; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Lu Y; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. yanlu001@fmmu.edu.cn., Wang Q; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. wqfmmu77@163.com.
Source: Neuroscience bulletin [Neurosci Bull] 2025 Jul; Vol. 41 (7), pp. 1161-1180. Date of Electronic Publication: 2025 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT<subscript>2C</subscript> Receptors.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22He+XL%22">He XL</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Jiang+ZH%22">Jiang ZH</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Huang+CC%22">Huang CC</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Zhao+JS%22">Zhao JS</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Gu+N%22">Gu N</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. yanlu001@fmmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Anesthesiology and Perioperative Medicine, Department of Pain Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. wqfmmu77@163.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>101256850 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1995-8218 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219958218%22">19958218 </searchLink><i>NLM ISO Abbreviation: </i>Neurosci Bull <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s12264-025-01383-7
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              Text: 2025 Jul
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