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The role and mechanism of quercetin in improving late-onset hypogonadism through network analysis and experimental validation.

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Title: The role and mechanism of quercetin in improving late-onset hypogonadism through network analysis and experimental validation.
Authors: Wu X; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China., Zhao H; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China., Huang X; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China., Lu P; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China., Zhang R; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China., Guan Q; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com., Yu C; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Sep; Vol. 398 (9), pp. 12031-12046. Date of Electronic Publication: 2025 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: The role and mechanism of quercetin in improving late-onset hypogonadism through network analysis and experimental validation.
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  Data: <searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Lu+P%22">Lu P</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Guan+Q%22">Guan Q</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. doctorguanqingbo@163.com.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.; Department of Endocrinology, Shandong Provincial Hospital, Shandong University of Traditional Chinese Medicine, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Institute of Endocrinology and Metabolic Diseases, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, No. 324, Jing Wu Wei Qi Road, Jinan, 250021, Shandong, China. yuchunxiao@sdfmu.edu.cn.
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