Physical activity and APOE neuropathology score modify the association of age and [11C]-PiB-PET amyloid burden in a cohort enriched with risk for Alzheimer's disease.

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Title: Physical activity and APOE neuropathology score modify the association of age and [11C]-PiB-PET amyloid burden in a cohort enriched with risk for Alzheimer's disease.
Authors: Blum EG; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Edmunds KJ; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Institute of Biomedical and Neural Engineering (IBNE), Reykjavík University, 101 Reykjavík, Iceland., Breidenbach B; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Cook N; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110., Driscoll I; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Lose SR; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Bendlin BB; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Ma Y; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Christian B; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Betthauser TJ; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Sager M; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Asthana S; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705., Johnson SC; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Cook DB; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705.; Department of Kinesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792., Okonkwo OC; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Mar 05. Date of Electronic Publication: 2025 Mar 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.03.01.25323157