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Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy.

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Title: Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy.
Authors: Mori Y; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan., van Dijk EHC; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands., Miyake M; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan. miyakem@kuhp.kyoto-u.ac.jp.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. miyakem@kuhp.kyoto-u.ac.jp., Hosoda Y; Hosoda Eye Clinic, Nishinomiya, Japan., den Hollander AI; Genomics Research Center, Abbvie, Cambridge, MA, USA., Yzer S; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands., Miki A; Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Chen LJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Ahn J; Seoul National University, College of Medicine, Seoul, Korea.; SMG-SNU Boramae Medical Center, Seoul, Korea., Takahashi A; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan., Morino K; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Nakao SY; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Hoyng CB; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands., Ng DSC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Cen LP; Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China., Chen H; Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China., Ng TK; Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China., Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China., Joo K; Seoul National University, College of Medicine, Seoul, Korea.; Seoul National University Bundang Hospital, Seongnam, Korea., Sato T; Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan., Sakata Y; Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Japan., Tajima A; Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan., Tabara Y; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Park KH; Seoul National University, College of Medicine, Seoul, Korea.; Seoul National University Hospital, Seoul, Korea., Matsuda F; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yamashiro K; Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku, Japan., Honda S; Department of Ophthalmology and Visual Sciences, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan., Nagasaki M; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Division of Biomedical Information Analysis, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Boon CJF; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Tsujikawa A; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.
Corporate Authors: Nagahama Study Group
Source: Scientific reports [Sci Rep] 2025 Mar 17; Vol. 15 (1), pp. 9158. Date of Electronic Publication: 2025 Mar 17.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy.
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  Data: <searchLink fieldCode="AU" term="%22Mori+Y%22">Mori Y</searchLink>; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22van+Dijk+EHC%22">van Dijk EHC</searchLink>; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Miyake+M%22">Miyake M</searchLink>; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan. miyakem@kuhp.kyoto-u.ac.jp.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. miyakem@kuhp.kyoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Hosoda+Y%22">Hosoda Y</searchLink>; Hosoda Eye Clinic, Nishinomiya, Japan.<br /><searchLink fieldCode="AU" term="%22den+Hollander+AI%22">den Hollander AI</searchLink>; Genomics Research Center, Abbvie, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yzer+S%22">Yzer S</searchLink>; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Miki+A%22">Miki A</searchLink>; Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Chen+LJ%22">Chen LJ</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ahn+J%22">Ahn J</searchLink>; Seoul National University, College of Medicine, Seoul, Korea.; SMG-SNU Boramae Medical Center, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Takahashi+A%22">Takahashi A</searchLink>; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.<br /><searchLink fieldCode="AU" term="%22Morino+K%22">Morino K</searchLink>; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nakao+SY%22">Nakao SY</searchLink>; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hoyng+CB%22">Hoyng CB</searchLink>; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ng+DSC%22">Ng DSC</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Cen+LP%22">Cen LP</searchLink>; Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; 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Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku, Japan.<br /><searchLink fieldCode="AU" term="%22Honda+S%22">Honda S</searchLink>; Department of Ophthalmology and Visual Sciences, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nagasaki+M%22">Nagasaki M</searchLink>; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Division of Biomedical Information Analysis, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Boon+CJF%22">Boon CJF</searchLink>; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tsujikawa+A%22">Tsujikawa A</searchLink>; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.
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