CAR-NK cell therapy combined with checkpoint inhibition induces an NKT cell response in glioblastoma.

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Title: CAR-NK cell therapy combined with checkpoint inhibition induces an NKT cell response in glioblastoma.
Authors: Strassheimer F; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Elleringmann P; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Ludmirski G; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany., Roller B; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Macas J; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany., Alekseeva T; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany., Cakmak P; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany., Aliraj B; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Goethe University, Institute of Biochemistry I, Faculty of Medicine, Frankfurt, Germany., Krenzlin H; University Medical Center Mainz, Department of Neurosurgery, Mainz, Germany., Demes MC; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Goethe University, Dr. Senckenberg Institute of Pathology, Goethe University Hospital, Frankfurt, Germany., Mildenberger IC; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Tonn T; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Institute for Transfusion Medicine and Immunohematology, German Red Cross Blood Donation Service Baden-Württemberg-Hessen and Goethe University Hospital, Frankfurt, Germany., Weber KJ; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany., Reiss Y; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany., Plate KH; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany., Weigert A; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Biochemistry I, Faculty of Medicine, Frankfurt, Germany., Wels WS; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany., Steinbach JP; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Burger MC; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany. burger@med.uni-frankfurt.de.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany. burger@med.uni-frankfurt.de.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. burger@med.uni-frankfurt.de.
Source: British journal of cancer [Br J Cancer] 2025 May; Vol. 132 (9), pp. 849-860. Date of Electronic Publication: 2025 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Strassheimer+F%22">Strassheimer F</searchLink>; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Elleringmann+P%22">Elleringmann P</searchLink>; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ludmirski+G%22">Ludmirski G</searchLink>; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Roller+B%22">Roller B</searchLink>; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Macas+J%22">Macas J</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Alekseeva+T%22">Alekseeva T</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Cakmak+P%22">Cakmak P</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Aliraj+B%22">Aliraj B</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Goethe University, Institute of Biochemistry I, Faculty of Medicine, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Krenzlin+H%22">Krenzlin H</searchLink>; University Medical Center Mainz, Department of Neurosurgery, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Demes+MC%22">Demes MC</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Goethe University, Dr. Senckenberg Institute of Pathology, Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Mildenberger+IC%22">Mildenberger IC</searchLink>; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Tonn+T%22">Tonn T</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; Institute for Transfusion Medicine and Immunohematology, German Red Cross Blood Donation Service Baden-Württemberg-Hessen and Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+KJ%22">Weber KJ</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Reiss+Y%22">Reiss Y</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Plate+KH%22">Plate KH</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Neurology (Edinger Institute), Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Weigert+A%22">Weigert A</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Goethe University, Institute of Biochemistry I, Faculty of Medicine, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Wels+WS%22">Wels WS</searchLink>; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbach+JP%22">Steinbach JP</searchLink>; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Burger+MC%22">Burger MC</searchLink>; Goethe University, Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany. burger@med.uni-frankfurt.de.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany. burger@med.uni-frankfurt.de.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. burger@med.uni-frankfurt.de.
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