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Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancer.

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Title: Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancer.
Authors: Taira A; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Aavikko M; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Katainen R; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Kaasinen E; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Välimäki N; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Ravantti J; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, FI-00014, Helsinki, Finland., Ristimäki A; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Department of Pathology, HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, 00014, Finland., Seppälä TT; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, 00290, Finland.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and TAYS Cancer Centre, 33520, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University, Tampere, 33100, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, 00014, Finland., Renkonen-Sinisalo L; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, 00290, Finland., Lepistö A; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, 00290, Finland., Tahkola K; Department of Surgery, The Wellbeing Services of Central Finland, Hoitajatie 1, 40620, Jyväskylä, Finland., Mattila A; Department of Surgery, The Wellbeing Services of Central Finland, Hoitajatie 1, 40620, Jyväskylä, Finland., Koskensalo S; The HUCH Gastrointestinal Clinic, Helsinki University Central Hospital, Helsinki, 00280, Finland., Mecklin JP; Department of Education and Research, The Wellbeing Services of Central Finland, Hoitajatie 1, 40620, Jyväskylä, Finland.; Department of Sport and Health Sciences, University of Jyväskylä, 40014, Jyväskylä, Finland., Böhm J; Department of Pathology, The Wellbeing Services of Central Finland, Hoitajatie 1, 40620, Jyväskylä, Finland., Bramsen JB; Department of Molecular Medicine, Aarhus University Hospital, DK-8200, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, DK-8200, Aarhus, Denmark., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, DK-8200, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, DK-8200, Aarhus, Denmark., Palin K; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, 00014, Finland., Rajamäki K; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Aaltonen LA; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland. lauri.aaltonen@helsinki.fi.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland. lauri.aaltonen@helsinki.fi.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, 00014, Finland. lauri.aaltonen@helsinki.fi.
Corporate Authors: iCAN
Source: Oncogene [Oncogene] 2025 Jun; Vol. 44 (22), pp. 1718-1730. Date of Electronic Publication: 2025 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Taira+A%22">Taira A</searchLink>; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.<br /><searchLink fieldCode="AU" term="%22Aavikko+M%22">Aavikko M</searchLink>; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Katainen+R%22">Katainen R</searchLink>; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Kaasinen+E%22">Kaasinen E</searchLink>; 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Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, 00014, Finland.<br /><searchLink fieldCode="AU" term="%22Rajamäki+K%22">Rajamäki K</searchLink>; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.<br /><searchLink fieldCode="AU" term="%22Aaltonen+LA%22">Aaltonen LA</searchLink>; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, 00014, Finland. lauri.aaltonen@helsinki.fi.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland. lauri.aaltonen@helsinki.fi.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, 00014, Finland. lauri.aaltonen@helsinki.fi.
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