Longitudinal Genomic Analysis to Fine-tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients with BRAFV600-Mutant Metastatic Melanoma.

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Title: Longitudinal Genomic Analysis to Fine-tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients with BRAFV600-Mutant Metastatic Melanoma.
Authors: Dummer R; Department of Dermatology, Skin Cancer Unit, University Hospital Zurich, Zurich, Switzerland., Sandhu S; Sir Peter MacCallum Cancer Department of Oncology, University of Melbourne, Melbourne, Australia., Miller WH Jr; Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, Montreal, Canada.; Department of Medicine, McGill University, Montreal, Canada.; Department of Oncology, McGill University, Montreal, Canada., Butler MO; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; Department of Medicine, University of Toronto, Toronto, Canada.; Department of Immunology, University of Toronto, Toronto, Canada., Taylor MH; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon., Heinzerling L; Department of Dermatology and Allergy, University Hospital, Ludwig Maximilian University, Munich, Germany., Blank CU; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Muñoz-Couselo E; Department of Medical Oncology, Melanoma and Other Skin Cancers Unit, Vall d'Hebron Hospital and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Burris HA 3rd; Sarah Cannon Research Institute, Nashville, Tennessee., Postow MA; Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York., Chmielowski B; Division of Hematology-Oncology, Department of Medicine, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California., Middleton MR; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.; Department of Oncology, University of Oxford, Oxford, United Kingdom.; Early Phase Clinical Trials Unit, Cancer & Haematology Centre, Churchill Hospital, Oxford, United Kingdom., Berking C; Department of Dermatology, Uniklinikum Erlangen, CCC Erlangen - EMN, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany., Hassel JC; Department of Dermatology and National Center for Tumor Diseases (NCT), Heidelberg University, Medical Faculty Heidelberg, NCT Heidelberg, A Partnership Between DKFZ and University Hospital Heidelberg, Heidelberg, Germany., Gesierich AH; Department of Dermatology, Venerology and Allergology, University Hospital Würzburg, Würzburg, Germany., Mauch C; Department of Dermatology and Venereology, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany., Kleha JF; Pfizer, New York, New York., Polli A; Pfizer, Milan, Italy., Harney AS; Pfizer Boulder Research Unit, Boulder, Colorado., di Pietro A; Pfizer, Milan, Italy., Ascierto PA; Melanoma, Cancer Immunotherapy and Innovative Therapies Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Jun 03; Vol. 31 (11), pp. 2097-2107.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-24-0254