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Structure and dynamics determine G protein coupling specificity at a class A GPCR.

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Title: Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Authors: Casiraghi M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Brennan PC; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA., Habrian C; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Hübner H; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany., Schmidt MF; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany., Maul L; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany., Pani B; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Bahriz SMFM; Department of Pharmacology, University of California, Davis, Davis, CA, USA., Xu B; Department of Pharmacology, University of California, Davis, Davis, CA, USA.; VA Northern California Health Care System, Mather, CA, USA., Staffen N; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany., Assafa TE; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA., Chen B; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA., White E; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Sunahara RK; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimo-Adachi-cho, Sakyo-ku, Kyoto 606-8501, Japan., Xiang YK; Department of Pharmacology, University of California, Davis, Davis, CA, USA.; VA Northern California Health Care System, Mather, CA, USA., Lefkowitz RJ; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA.; HHMI, Duke University Medical Center, Durham, NC, USA., Isacoff EY; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA., Nucci N; Department of Physics and Astronomy and Department of Biological and Biomedical Biosciences, Rowan University, Glassboro, NJ, USA., Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany., Lerch MT; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Source: Science advances [Sci Adv] 2025 Mar 21; Vol. 11 (12), pp. eadq3971. Date of Electronic Publication: 2025 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Casiraghi+M%22">Casiraghi M</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brennan+PC%22">Brennan PC</searchLink>; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Habrian+C%22">Habrian C</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hübner+H%22">Hübner H</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+MF%22">Schmidt MF</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Maul+L%22">Maul L</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Pani+B%22">Pani B</searchLink>; Department of Medicine, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bahriz+SMFM%22">Bahriz SMFM</searchLink>; Department of Pharmacology, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+B%22">Xu B</searchLink>; Department of Pharmacology, University of California, Davis, Davis, CA, USA.; VA Northern California Health Care System, Mather, CA, USA.<br /><searchLink fieldCode="AU" term="%22Staffen+N%22">Staffen N</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Assafa+TE%22">Assafa TE</searchLink>; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22White+E%22">White E</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sunahara+RK%22">Sunahara RK</searchLink>; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Inoue+A%22">Inoue A</searchLink>; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimo-Adachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.<br /><searchLink fieldCode="AU" term="%22Xiang+YK%22">Xiang YK</searchLink>; Department of Pharmacology, University of California, Davis, Davis, CA, USA.; VA Northern California Health Care System, Mather, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lefkowitz+RJ%22">Lefkowitz RJ</searchLink>; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA.; HHMI, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Isacoff+EY%22">Isacoff EY</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nucci+N%22">Nucci N</searchLink>; Department of Physics and Astronomy and Department of Biological and Biomedical Biosciences, Rowan University, Glassboro, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Gmeiner+P%22">Gmeiner P</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Lerch+MT%22">Lerch MT</searchLink>; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Kobilka+BK%22">Kobilka BK</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
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