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Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease.

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Title: Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease.
Authors: Phillips JM; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Dumitrescu LC; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Archer DB; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Regelson AN; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Lee ML; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Choi SE; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Scollard P; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Trittschuh EH; Department of Psychiatry and Behavior Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.; VA Puget Sound Health Care System, Geriatric Research Education and Clinical Center, Seattle, WA 98108, USA., Kukull WA; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA., Biber S; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA., Mez J; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA., Mahoney ER; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Clifton M; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Libby JB; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Walters S; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Bush WS; Cleveland Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Engelman CD; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA., Lu Q; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.; Department of Statistics, University of Wisconsin-Madison, Madison, WI 53706, USA.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53706, USA., Fardo DW; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY 40536, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA., Widaman KF; Graduate School of Education, University of California at Riverside, Riverside, CA 92521, USA., Buckley RF; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.; Center of Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.; Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC 3010, Australia., Mormino EC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA., Sanders RE; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Clark LR; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.; Geriatric Research and Education Center, William S. Middleton Memorial Veteran's Hospital, Madison, WI 53705, USA., Gifford KA; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Vardarajan B; Department of Neurology, Columbia University, New York, NY 10032, USA.; The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, NY 10032, USA.; The Institute of Genomic Medicine, Columbia University Medical Center and The New York Presbyterian Hospital, New York, NY 10032, USA., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL 33136, USA.; Dr John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, FL 33136, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL 33136, USA., Farrer LA; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA 02118, USA., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Haines JL; Cleveland Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Jefferson AL; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Johnson SC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA., Albert MS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Keene CD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Saykin AJ; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Risacher SL; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Larson EB; Department of Medicine, University of Washington, Seattle, WA 98195, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA., Sperling RA; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.; Center of Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA., Mayeux R; Department of Neurology, Columbia University, New York, NY 10032, USA.; The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, NY 10032, USA., Goate AM; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Renton AE; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Marcora E; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Fulton-Howard B; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Patel T; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA., Hassenstab J; Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA., Belloy ME; Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA., Andrews SJ; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94143, USA., Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Bilgel M; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224, USA., An Y; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Beason-Held LL; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Walker KA; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Duggan MR; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Klinedinst BS; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Crane PK; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Source: Brain : a journal of neurology [Brain] 2025 Aug 01; Vol. 148 (8), pp. 2714-2729.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
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  Data: Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Phillips+JM%22">Phillips JM</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Dumitrescu+LC%22">Dumitrescu LC</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Archer+DB%22">Archer DB</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Regelson+AN%22">Regelson AN</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Lee+ML%22">Lee ML</searchLink>; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Choi+SE%22">Choi SE</searchLink>; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Scollard+P%22">Scollard P</searchLink>; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Trittschuh+EH%22">Trittschuh EH</searchLink>; Department of Psychiatry and Behavior Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.; VA Puget Sound Health Care System, Geriatric Research Education and Clinical Center, Seattle, WA 98108, USA.<br /><searchLink fieldCode="AU" term="%22Kukull+WA%22">Kukull WA</searchLink>; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Biber+S%22">Biber S</searchLink>; 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Cleveland Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Engelman+CD%22">Engelman CD</searchLink>; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Q%22">Lu Q</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.; Department of Statistics, University of Wisconsin-Madison, Madison, WI 53706, USA.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53706, USA.<br /><searchLink fieldCode="AU" term="%22Fardo+DW%22">Fardo DW</searchLink>; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY 40536, USA.; 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Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.; Geriatric Research and Education Center, William S. 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Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Fulton-Howard+B%22">Fulton-Howard B</searchLink>; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Patel+T%22">Patel T</searchLink>; Ronald M. 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            – D: 01
              M: 08
              Text: 2025 Aug 01
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1460-2156
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              Value: 148
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Brain : a journal of neurology
              Type: main
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