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Comparison of enriched charge variants from different anti-CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post-translational modification.

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Title: Comparison of enriched charge variants from different anti-CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post-translational modification.
Authors: Nguyen JB; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Liu S; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Howie DA; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Oberholtzer ZR; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Ong ET; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Rao R; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Prinston JE; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Dikiy I; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Wu J; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Wu Z; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Zhao Y; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Li M; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Molden R; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Molina G; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Provoncha K; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Sandu C; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Qiu H; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Li N; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Matousek W; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Rosconi MP; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Pyles EA; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Source: Protein science : a publication of the Protein Society [Protein Sci] 2025 Apr; Vol. 34 (4), pp. e70079.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparison of enriched charge variants from different anti-CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post-translational modification.
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  Data: <searchLink fieldCode="AU" term="%22Nguyen+JB%22">Nguyen JB</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Howie+DA%22">Howie DA</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Oberholtzer+ZR%22">Oberholtzer ZR</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ong+ET%22">Ong ET</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rao+R%22">Rao R</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Prinston+JE%22">Prinston JE</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Dikiy+I%22">Dikiy I</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Molden+R%22">Molden R</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Molina+G%22">Molina G</searchLink>; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Provoncha+K%22">Provoncha K</searchLink>; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Sandu+C%22">Sandu C</searchLink>; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Li+N%22">Li N</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Matousek+W%22">Matousek W</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rosconi+MP%22">Rosconi MP</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Pyles+EA%22">Pyles EA</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
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