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The Impact of the Tumor Microenvironment on the Effect of IL-1β Blockade in NSCLC: Biomarker Analyses from CANOPY-1 and CANOPY-N Trials.

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Title: The Impact of the Tumor Microenvironment on the Effect of IL-1β Blockade in NSCLC: Biomarker Analyses from CANOPY-1 and CANOPY-N Trials.
Authors: Solomon BJ; Peter MacCallum Cancer Centre, Melbourne, Australia., Tan DSW; National Cancer Centre Singapore, Duke-NUS Medical School, Singapore, Singapore., de Castro G Jr; Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil., Cobo M; Medical Oncology Intercenter Unit, Regional University Hospital and Virgen de la Victoria University Hospital, IBIMA, Málaga, Spain., Garassino MC; Department of Medicine, Section Hematology Oncology, Thoracic Oncology, University of Chicago, Chicago, Illinois., Zhang J; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas., Johnson BE; Dana-Farber Cancer Institute, Boston, Massachusetts., Lee JM; UCLA Health, Los Angeles, California., Garrido P; Hospital Universitario Ramón y Cajal, Madrid, Spain., Butler AA; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey., Pelletier MR; Novartis BioMedical Research, Cambridge, Massachusetts., Savchenko A; Precision Medicine, Novartis Pharmaceuticals Corporation, Cambridge, Massachusetts., Ji L; Novartis BioMedical Research, Cambridge, Massachusetts., Brase JC; Novartis Pharma AG, Basel, Switzerland., Caparica R; Novartis Pharma AG, Basel, Switzerland., Demanse D; Novartis Pharma AG, Basel, Switzerland., Wu J; Novartis BioMedical Research, Cambridge, Massachusetts., Bossen C; Novartis Pharma AG, Basel, Switzerland., Mok T; The Chinese University of Hong Kong, Hong Kong, China.
Source: Cancer research communications [Cancer Res Commun] 2025 Apr 01; Vol. 5 (4), pp. 632-646.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The Impact of the Tumor Microenvironment on the Effect of IL-1β Blockade in NSCLC: Biomarker Analyses from CANOPY-1 and CANOPY-N Trials.
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  Data: <searchLink fieldCode="AU" term="%22Solomon+BJ%22">Solomon BJ</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Tan+DSW%22">Tan DSW</searchLink>; National Cancer Centre Singapore, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22de+Castro+G+Jr%22">de Castro G Jr</searchLink>; Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cobo+M%22">Cobo M</searchLink>; Medical Oncology Intercenter Unit, Regional University Hospital and Virgen de la Victoria University Hospital, IBIMA, Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Garassino+MC%22">Garassino MC</searchLink>; Department of Medicine, Section Hematology Oncology, Thoracic Oncology, University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.<br /><searchLink fieldCode="AU" term="%22Johnson+BE%22">Johnson BE</searchLink>; Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lee+JM%22">Lee JM</searchLink>; UCLA Health, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Garrido+P%22">Garrido P</searchLink>; Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Butler+AA%22">Butler AA</searchLink>; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.<br /><searchLink fieldCode="AU" term="%22Pelletier+MR%22">Pelletier MR</searchLink>; Novartis BioMedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Savchenko+A%22">Savchenko A</searchLink>; Precision Medicine, Novartis Pharmaceuticals Corporation, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ji+L%22">Ji L</searchLink>; Novartis BioMedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Brase+JC%22">Brase JC</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Caparica+R%22">Caparica R</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Demanse+D%22">Demanse D</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Novartis BioMedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bossen+C%22">Bossen C</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mok+T%22">Mok T</searchLink>; The Chinese University of Hong Kong, Hong Kong, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918281580506676 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2767-9764 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227679764%22">27679764 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res Commun <i>Subsets: </i>MEDLINE
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              Text: 2025 Apr 01
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